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Dorsoventral patterning and oligodendroglial specification in the developing central nervous system
Rebecca J. Hardy,
Corresponding Author
Rebecca J. Hardy
Brookdale Center for Developmental and Molecular Biology, Mount Sinai Medical Center, New York, New York
Brookdale Center for Developmental and Molecular Biology, Mount Sinai Medical Center, Box 1126, 1 Gustave L. Levy Place, New York, NY 10029Search for more papers by this authorRebecca J. Hardy,
Corresponding Author
Rebecca J. Hardy
Brookdale Center for Developmental and Molecular Biology, Mount Sinai Medical Center, New York, New York
Brookdale Center for Developmental and Molecular Biology, Mount Sinai Medical Center, Box 1126, 1 Gustave L. Levy Place, New York, NY 10029Search for more papers by this authorFirst published: 07 December 1998
Citations: 26
Abstract
While the bulk of oligodendendrocytes are generated postnatally in rodents, it is now clear that the first oligodendrocytes are born during midembryonic development. Recent studies imply that the first oligodendrocytes to appear are specified concurrently with certain neuronal subtypes. In addition, patterning molecules known to confer positional information on neural tissues during development, such as sonic hedgehog and bone morphogenetic proteins, have also been implicated in the specification of glial fate. This review discusses some of the recent advances in our knowledge of how oligodendrocytes are generated and the mechanisms by which this might occur in the developing brain and spinal cord. J. Neurosci. Res. 50:139–145, 1997. © 1997 Wiley-Liss, Inc.
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