Combined angioma and glioma (angioglioma)
Corresponding Author
Vira Kasantikul MD
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Department of Pathology, Chulalongkorn Hospital, Bangkok 10330, ThailandSearch for more papers by this authorSamruay Shuangshoti MD
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorViratt Panichabhongse MD
Department of Surgery, Bangkok General Hospital, Bangkok, Thailand
Search for more papers by this authorMartin G. Netsky MD
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee
Search for more papers by this authorCorresponding Author
Vira Kasantikul MD
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Department of Pathology, Chulalongkorn Hospital, Bangkok 10330, ThailandSearch for more papers by this authorSamruay Shuangshoti MD
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Search for more papers by this authorViratt Panichabhongse MD
Department of Surgery, Bangkok General Hospital, Bangkok, Thailand
Search for more papers by this authorMartin G. Netsky MD
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee
Search for more papers by this authorAbstract
Ten patients in whom tissue proliferation akin to angioglioma occurred within the brain are described; seven of the lesions were supratentorial and three infratentorial. Only 31 accepted instances of such neoplasms have been found in the literature. The combined lesions usually become symptomatic in the second and third decades. In all 10 cases, the angiomatous part of the combined tumors showed characteristic vascular malformation such as severe hyalinization, tortuosity, and some were even calcified. The number of abnormal blood vessels were excessive in all examples. The glial portion consisted of either astrocytoma, oligodendroglioma, or mixtures of these gliomas. Dedifferentiation of the neuroglia combined with neoplastic endothelial proliferation indicates the true neoplastic nature rather than reactive gliosis associated with a vascular anomaly. © 1996 Wiley-Liss, Inc.
References
- 1 DS Russell, LJ Rubinstein (eds): “ Pathology of Tumours of the Nervous System,” 5th ed. London: Edward Arnold, 1989, p 93–160.
- 2 Courville CB: Intracranial tumors: Note upon series of three thousand verified cases with some current observations pertaining to their mortality. Bull Los Angeles Neurol Soc 32(Suppl 2): 1–80, 1967.
- 3 Bonnin JM, Pena CE, Rubinstein LJ: Mixed capillary hemangio-blastoma and glioma: A redefinition of the “angioglioma”. J Neuropathol Exp Neurol 42: 504–516, 1983.
- 4 Chee CP, Johnston R, Doyle D, Macpherson P: Oligodendroglioma and cerebral cavernous angioma: Case report. J Neurosurg 62: 145–147, 1985.
- 5 Crowell RM, DeGirolami U, Sweet WH: Arteriovenous malformation and oligodendroglioma: Case report. J Neurosurg 43: 108–111, 1975.
- 6 Shuangshoti S, Netsky MG, Switter DJ: Combined congenital vascular anomalies and neuroepithelial (colloid) cysts. Neurology 28: 552–555, 1978.
- 7 Kasantikul V, Brown WJ: Lipomatous meningioma associated with cerebral vascular malformation. J Surg Oncol 26: 35–39, 1984.
- 8 Kasantikul V, Netsky MG: Combined neurilemmoma and angioma: Tumor of ectomesenchyme and a source of bleeding. J Neurosurg 50: 81–89, 1979.
- 9 Rubinstein LJ: Tumors of the central nervous system. In: “ Atlas of Tumor Pathology,” Series, Fascicle 6. Washington, DC: Armed Forces Institute of Pathology, 1972, 49.
- 10 Henschen F: Tumoren des Zentralnervensystems und seiner Hullen. In O Lubarsch, F Henke, R Rössle (eds): “ Handbuch der Speziellen Pathologischen, Anatomie und Histologie,” Vol 13, part 3. Berlin: Springer-Verlag, 1955. p 413–735.
- 11 Zülch KJ: “ Brain Tumors: Their Biology and Pathology,” 2nd ed. New York: Springer-Verlag, 1965. p 1–326.
- 12 Koella W: Das angiogliom. Schweiz Arch Neurol Psychiat 59: 208–238, 1947.
- 13 Roussy G. Oberling CH: Les tumeurs angiomateuses des centres nerveux. Presse Med 38: 179–185, 1930.
- 14 Waggener JD, Beggs JL: Vasculature of neural neoplasms. In RA Thompson, JR Green (eds): “ Advances in Neurology.” New York: Raven Press. 1976. p 27–49.
- 15 Swenberg JA, Koestner A, Wechsler W, et al.: Differential oncogenic effects on methylnitrosourea. J Natl Cancer Inst 54: 89–96, 1975.
- 16 MG Netsky, S Shuangshoti (eds): “ The Choroid Plexus in Health and Disease.” Bristol: John Wright, 1975. p 217–220.
- 17 Doe FD, Shuangshoti S, Netsky MG: Cryptic hemangioma of the choroid plexus: A cause of intraventricular hemorrhage. Neurology 22: 1232–1239, 1972.
- 18 Kelly PJ, Suddith RL, Hutchison HT, et al.: Endothelial growth factor present in tissue culture of CNS tumors. J Neurosurg 44: 342–346, 1976.
- 19 Fischer EG, Sotrel A, Welch K: Cerebral hemangioma with glial neoplasia (angioglioma?): Report of two cases. J Neurosurg 56: 430–434, 1982.
- 20 Lombardi D, Schetthauer BW, Piepgras D, et al.: “Angioglioma” and the arteriovenous malformation-glioma association. J Neurosurg 75: 589–596, 1991.
- 21 Malcolm GP, Symon L, Tan LC, Pires M: Astrocytoma and associated arteriovenous malformation. Surg Neurol 36: 59–62, 1991.
- 22 Shuangshoti S. Panyathanya R: Intracranial angiogliomas. J Med Assoc Thai 66: 799–811, 1983.
- 23 Voss O: Zur differentialdiagnose der sarkomatösen hirngeschwülste. Zentralbl Neurochir 1: 76–79. 1936.
- 24 Weiss A: Über einen kombinationstumor des gehirns (echtes angiogliom). Frankfurt Ztschr Path 44: 144–160, 1932.
- 25 Zuccarello M, Giordano R, Scanarini M, Mingrino S: Malignant astrocytoma associated with arteriovenous malformation: Case report. Acta Neurochir 50: 305–309, 1979.
- 26 Fine RD, Paterson A, Gaylor JB: Recurrent attacks of subarachnoid hemorrhage in the presence of a cerebral angioma and intraventricular oligodendroglioma. Scot Med J 5: 342–346, 1960.
- 27 Heffner RR Jr, Porro RS, Deek MDF: Benign astrocytoma associated with arteriovenous malformation. Case report. J Neurosurg 35: 229–233, 1971.
- 28
Ho KL,
Wolfe DE:
Concurrence of multiple sclerosis and primary intracranial neoplasms.
Cancer
47: 2913–2919,
1981.
10.1002/1097-0142(19810615)47:12<2913::AID-CNCR2820471229>3.0.CO;2-1 CAS PubMed Web of Science® Google Scholar
- 29 Licata C, Pasqualin A, Freschini A, et al.: Management of associated primary cerebral neoplasms and vascular malformations: 2. Intracranial arteriovenous malformations. Acta Neurochir 83: 38–46, 1986.
- 30 Martinez-Lage JF, Poza M, Esteban JA, Sola J: Subarachnoid hemorrhage in the presence of a cerebral arteriovenous malformation and an intraventricular oligodendroglioma: Case report. Neurosurgery 19: 125–128, 1986.
- 31 Warren GC: Intracranial arteriovenous malformation, pulmonary arteriovenous fistula, and malignant glioma in the same patients: Case report. J Neurosurg 30: 618–621, 1969.
- 32 Welcker ER, Eeidel K: Combination of an arteriovenous aneurysmatic angioma with an astrocytoma. Deutsch Z Nervenheilk 189: 231–239, 1966.
- 33 White RJ, Kemohan JW, Wood MW: A study of fifty intracranial vascular tumors found incidentally at necropsy. J Neuropathol Exp Neurol 17: 392–398, 1958.
- 34 Goodkin R, Zaias B, Michelsen WJ: Arteriovenous malformation and glioma: Coexistent or sequential? Case report. J Neurosurg 72: 798–805, 1990.
- 35 Groothuis DR, Fischer JM, Vick NA, Bigner DD: Experimental gliomas: An autoradiographic study of the endothelial component. Neurology 30: 297–301, 1980.
- 36 McCormick WF: Report on the cooperative study on intracranial aneurysms: The pathology of vascular (“arteriovenous”) malformations. J Neurosurg 24: 807–816, 1966.
- 37 Glass B, Abbott KH: Subarachnoid hemorrhage consequent to intracranial tumors. Arch Neurol Psychiatr 73: 369–379, 1955.
- 38 Kasantikul V, Wirt TC, Allen VA, Netsky MG: Identification of a brain stone as calcified hemangioma. J Neurosurg 52: 862–866, 1980.
