Volume 49, Issue 1 pp. 85-89
Communication to the Editor
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Preparation of Novel Hexythiazox Analogues

Lajos Novák

Lajos Novák

Institute for Organic Chemistry, Technical University, Szt. Gellért tér 4. H-1521 Budapest, Hungary

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Gábor Hornyánszky

Gábor Hornyánszky

Institute for Organic Chemistry, Technical University, Szt. Gellért tér 4. H-1521 Budapest, Hungary

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János Rohály

János Rohály

Institute for Organic Chemistry, Technical University, Szt. Gellért tér 4. H-1521 Budapest, Hungary

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Pál Kolonits

Pál Kolonits

Institute for Organic Chemistry, Technical University, Szt. Gellért tér 4. H-1521 Budapest, Hungary

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Csaba Szántay

Corresponding Author

Csaba Szántay

Central Research Institute of Chemistry, Hungarian Academy of Sciences, PO Box 17, H-1525 Budapest, Hungary

Central Research Institute of Chemistry, Hungarian Academy of Sciences, PO Box 17, H-1525 Budapest, HungarySearch for more papers by this author

Abstract

Novel analogues of the title compound were prepared in several steps: via addition of methylmagnesium iodide to an acetamide derivative to yield diastereomeric amino alcohols, followed by hydrolysis, cyclization to the corresponding oxazole or thiazole derivative, and a coupling reaction with isocyanates. Results from acaricidal tests showed the compounds to be 100 times less active than hexythiazox. © 1997 SCI.

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