Volume 64, Issue 1 pp. 71-72
Brief Report
Free Access

Folate sufficient subjects do not accumulate additional folates during supplementation

C.R. Santhosh-Kumar

C.R. Santhosh-Kumar

Department of Medicine, Royal Hospital, Muscat, Oman

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James S. Bisping

James S. Bisping

Division of Hematology, University of Colorado Health Sciences Center and Denver VAH, Denver, Colorado

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Steven D. Kick

Steven D. Kick

Division of General Internal Medicine, University of Colorado Health Sciences Center and Denver VAH, Denver, Colorado

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John C. Deutsch

John C. Deutsch

Division of Hematology, University of Colorado Health Sciences Center and Denver VAH, Denver, Colorado

Division of Gastroenterology, University of Colorado Health Sciences Center and Denver VAH, Denver, Colorado

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J. Fred Kolhouse

Corresponding Author

J. Fred Kolhouse

Division of Hematology, University of Colorado Health Sciences Center and Denver VAH, Denver, Colorado

Division of Hematology, University of Colorado Health Sciences Center and Denver VAH, 4200 East Ninth Avenue, B-170, Denver, COSearch for more papers by this author

Abstract

In a double-blinded placebo-controlled trial of folic acid supplementation in 82 alcoholic subjects, it was found that whole blood folate levels, determined by a mass spectrometric method, do not increase in subjects whose baseline folate levels are above the third quartile (folate sufficiency). Since a state of folate sufficiency can now be identified, a recommended daily allowance (RDA) for folate can be determined using objective means. Am. J. Hematol. 64:71–72, 2000. © 2000 Wiley-Liss, Inc.

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