Volume 33, Issue 6 612030 pp. 309-312
Article
Open Access

Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Ana Lúcia G. Demarco

Ana Lúcia G. Demarco

Department of Ophthalmology Otorhinolaringology and Head and Neck Surgery School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
Maria de Lourdes V. Rodrigues

Maria de Lourdes V. Rodrigues

Department of Ophthalmology Otorhinolaringology and Head and Neck Surgery School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
José Fernando C. Figueiredo

José Fernando C. Figueiredo

Department Medical Clinical School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
Neifi Hassam S. Deghaide

Neifi Hassam S. Deghaide

Department Medical Clinical School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
Marcelo Bezerra de Menezes

Marcelo Bezerra de Menezes

Department Medical Clinical School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
Luís A. Demarco

Luís A. Demarco

Department of Ophthalmology Otorhinolaringology and Head and Neck Surgery School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
Ana Paula M. Fernandes

Corresponding Author

Ana Paula M. Fernandes

Department of General and Specialized Nursing Nursing School of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
Eduardo A. Donadi

Eduardo A. Donadi

Department Medical Clinical School of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto SP, Brazil , usp.br

Search for more papers by this author
First published: 21 May 2013

Abstract

Background/aims: The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).

Methods: 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.

Results: The HLA-B35 was significantly increased in TRC group (p = 0.0038).

Conclusion: The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.