The hypopigmentary action of KI-063 (a new tyrosinase inhibitor) combined with terrein
Dong-Seok Kim
Department of Biochemistry, College of Medicine, Chung-Ang University, 221 Heukseok-Dong Dongjak-Gu, Seoul 156-756, Republic of Korea
Search for more papers by this authorSangku Lee
National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333, Korea
Search for more papers by this authorHyun-Kyung Lee
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Search for more papers by this authorSeo-Hyoung Park
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Welskin Co. Ltd, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea
Search for more papers by this authorIn-Ja Ryoo
National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333, Korea
Search for more papers by this authorIck-Dong Yoo
National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333, Korea
Search for more papers by this authorSun-Bang Kwon
Welskin Co. Ltd, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea
Search for more papers by this authorKwang Jin Baek
Department of Biochemistry, College of Medicine, Chung-Ang University, 221 Heukseok-Dong Dongjak-Gu, Seoul 156-756, Republic of Korea
Search for more papers by this authorJung-Im Na
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Search for more papers by this authorCorresponding Author
Kyoung-Chan Park
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Department of Dermatology, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam-Si, Kyoungki-Do 463-707, Korea. E-mail: [email protected]Search for more papers by this authorDong-Seok Kim
Department of Biochemistry, College of Medicine, Chung-Ang University, 221 Heukseok-Dong Dongjak-Gu, Seoul 156-756, Republic of Korea
Search for more papers by this authorSangku Lee
National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333, Korea
Search for more papers by this authorHyun-Kyung Lee
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Search for more papers by this authorSeo-Hyoung Park
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Welskin Co. Ltd, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea
Search for more papers by this authorIn-Ja Ryoo
National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333, Korea
Search for more papers by this authorIck-Dong Yoo
National Cosmeceutical Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oeun-Dong, Yuseong-Gu, Daejeon 305-333, Korea
Search for more papers by this authorSun-Bang Kwon
Welskin Co. Ltd, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea
Search for more papers by this authorKwang Jin Baek
Department of Biochemistry, College of Medicine, Chung-Ang University, 221 Heukseok-Dong Dongjak-Gu, Seoul 156-756, Republic of Korea
Search for more papers by this authorJung-Im Na
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Search for more papers by this authorCorresponding Author
Kyoung-Chan Park
Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea
Department of Dermatology, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Seongnam-Si, Kyoungki-Do 463-707, Korea. E-mail: [email protected]Search for more papers by this authorAbstract
Resorcinol derivatives are known to inhibit melanin synthesis. In this study, resorcinol derivatives were synthesized and screened for their activity on melanogenesis. KI-063 (a tyrosinase inhibitor) was examined for its effects on melanogenesis using a spontaneously immortalized mouse melanocyte cell line (Mel-Ab). In a cell-free system, KI-063 directly inhibited tyrosinase, the rate-limiting melanogenic enzyme. Moreover, in a cell system, it inhibited melanin synthesis in a concentration-dependent manner. In addition, KI-063 inhibited the activity of cellular tyrosinase. Thus, this study examined the effects of a combination of KI-063 with terrein, an agent that down-regulates microphthalmia-associated transcription factor. The data suggest that KI-063 has an additive effect in combination with terrein. Thus, the suppression of tyrosinase activity by KI-063 and the inhibition of tyrosinase production by terrein appear to be an optimal combination for skin whitening.
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