Selective effect of oleamide, an endogenous sleepinducing lipid amide, on pentylenetetrazole-induced seizures in mice
Corresponding Author
Chun-Fu Wu
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
3Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China; E-mail: [email protected]; [email protected]Search for more papers by this authorChun-Li Li
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorHong-Rui Song
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Department of Organic Chemistry, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorHua-Feng Zhang
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorJing-Yu Yang
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorYu-Ling Wang
Department of Organic Chemistry, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorCorresponding Author
Chun-Fu Wu
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
3Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China; E-mail: [email protected]; [email protected]Search for more papers by this authorChun-Li Li
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorHong-Rui Song
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Department of Organic Chemistry, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorHua-Feng Zhang
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorJing-Yu Yang
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorYu-Ling Wang
Department of Organic Chemistry, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China
Search for more papers by this authorAbstract
The anti-seizure effect of oleamide, an endogenous sleep-inducing fatty acid amide, was studied in mice. Oleamide, in the dose range 43.7–700.0 mg kg−, significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole. However, oleamide showed no inhibitory action on the seizures induced by picrotoxin, strychnine, caffeine or semicarbazide. These results provide the first evidence for the anti-seizure effect of oleamide, and suggest that this effect may be selective to the seizure model induced by pentylenetetrazole.
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