Erratum to “DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil”
The purpose of this note is to correct both the analysis and typographical errors.
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The abstract, line 6: In “in 6 patients (8%)” should read “in 5 patients (6%)”.
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Page 4, line 12: In “8% (6) of the samples, being 5 missens” should read “6% (5) of the samples, being 4 missense”.
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Page 4, line 19: In “Of the 6 cases” should read “Of the 5 cases”.
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Page 4, line 20: In “(5, or 83.3%)” should read “(4, or 80%)”.
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Page 4, second column, line 8: In “OS for patients with wild DNMT3A gene was 41.4% and for patients with mutated DNMT3A was 44.4% (P = 0.59)” should read “OS for patients with wild DNMT3A gene was 45.7% and for patients with mutated DNMT3A was 60.0% (P = 0.47)”.
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Page 6, line 4: In “found in 8%” should read “found in 6%”.
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Page 6, second column, line 13: In “3 of 6 mutations” should read “3 of 5 mutations”.
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Page 6, second column, line 16: In “Five, or 80%,” should read “Four, or 80%,”.
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Page 6, second column, line 18: In “(P = 0.28)” should read “(P = 0.34)”.
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Page 6, second column, line 20: In “(20.7 × 109/L)” should read “(15.6 × 109/L)”.
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Table 4, column 2, line 6: In “H896*” should read “P896*”.
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Table 4: Entire line 7 was excluded.
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Table 5, line 2: In “40.2, 44.8 and 0.56” should read “47.4, 40.4 and 0.42”.
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Table 5, line 4: In “50% (3), 59.3% (45) and 0.68” should read “60% (3), 57.9% (44) and 0.92”.
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Table 5, line 5: In “50% (3), 40.7% (31)” should read “40% (2), 42.1% (32)”.
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Table 5, line 19: In “50% (3), 51.4% (37) and 1.000” should read “40% (2), 52.7% (39) and 0.66”.
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Table 5, line 20: In “50% (2), 30.9% (17) and 0.58” should read “40% (2), 29.2% (21) and 0.63”.
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We changed Figure 3 as shown above.
| Patient identification | Mutation | Allelic change | Exon | Type of mutation | FAB subtype | PCR | Risk group | Karyotype |
|---|---|---|---|---|---|---|---|---|
| 39 | D748N | G > A | 19 | Missense | M1 | Negative | Intermediate | Normal |
| 79 | R882H | G > A | 23 | Missense | M1 | Negative | Intermediate | Trisomy (8)(9) |
| 4 | R882H | G > A | 23 | Missense | M3 | Negative | Intermediate | Normal |
| 70 | R882H | G > A | 23 | Missense | M2 | Negative | Intermediate | Normal |
| 41 | P896* | A > G | 23 | Silent | M3 | PML/RARα | Favorable | t(15;17) |
| Characteristics | Number of pts (%) DNMT3A mutated | Number of pts (%) DNMT3A not mutated | P |
|---|---|---|---|
| Age (median) | 47.4 | 40.4 | 0.42 |
| Sex | |||
| Male | 60% (3) | 57.9% (44) | 0.92 |
| Female | 40% (2) | 42.1% (32) | |
| Subtype FAB | |||
| M0 | 0% | 7.2% (5) | |
| M1 | 60% (3) | 18.8% (13) | |
| M2 | 20% (1) | 30.4% (21) | 0.56 |
| M3 | 20% (1) | 20.3% (14) | |
| M4 | 0% | 18.8% (13) | |
| M5 | 0% | 1.4% (1) | |
| Not M3 | 0% | 2.9% (2) | |
| Risk groups | |||
| Favorable | 20% (1) | 29.8% (17) | |
| Intermediate | 80% (4) | 59.6% (34) | 1.000 |
| Unfavorable | 0% | 10.5% (6) | |
| Leukocytes (×103) (median) | 20.67 | 6.41 | 0.28 |
| Death | 40% (2) | 52.7% (39) | 0.66 |
| Relapses | 40% (2) | 29.2% (21) | 0.63 |
| Refractory | 20% (1) | 19.1% (13) | 0.96 |
