Disease Markers
Volume 24, Issue 4-5 747343 pp. 251-255
Article
Open Access

TGF-β Signaling in Neuronal Stem Cells

Chohee Yun, 

Chohee Yun

Laboratory of Developmental Neurobiology Department of Surgery Medicine & Lombardi Cancer Center Georgetown University, Washington, DC 20007, USA , georgetown.edu

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Jonathan Mendelson, 

Jonathan Mendelson

Laboratory of Developmental Neurobiology Department of Surgery Medicine & Lombardi Cancer Center Georgetown University, Washington, DC 20007, USA , georgetown.edu

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Tiffany Blake, 

Tiffany Blake

Laboratory of Developmental Neurobiology Department of Surgery Medicine & Lombardi Cancer Center Georgetown University, Washington, DC 20007, USA , georgetown.edu

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Lopa Mishra, 

Lopa Mishra

Laboratory of Developmental Neurobiology Department of Surgery Medicine & Lombardi Cancer Center Georgetown University, Washington, DC 20007, USA , georgetown.edu

Department of Veterans Affairs Washington DC 20049, USA

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Bibhuti Mishra, 

Corresponding Author

Bibhuti Mishra

Laboratory of Developmental Neurobiology Department of Surgery Medicine & Lombardi Cancer Center Georgetown University, Washington, DC 20007, USA , georgetown.edu

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First published: 21 May 2008
https://doi.org/10.1155/2008/747343
Citations: 11

Abstract

Transforming growth factor beta (TGF-β) signaling has diverse and complex roles in various biological phenomena such as cell growth, differentiation, embryogenesis and morphogenesis. ES cells provide an essential model for understanding the role of TGF-β signaling in lineage specification and differentiation. Recent studies have suggested significant role of TGF-β in stem/progenitor cell biology. Here in this review, we focus on the role of the TGF-β superfamily in neuronal development.

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