Volume 21, Issue 6 pp. 496-506
Review Article

Lung xenotransplantation: recent progress and current status

Donald G. Harris

Donald G. Harris

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA

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Kevin J. Quinn

Kevin J. Quinn

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

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Siamak Dahi

Siamak Dahi

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

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Lars Burdorf

Lars Burdorf

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

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Agnes M. Azimzadeh

Agnes M. Azimzadeh

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

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Richard N. Pierson III

Corresponding Author

Richard N. Pierson III

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA

Surgical Care Clinical Center, VA Maryland Health Care Center, Baltimore, MD, USA

Address reprint requests to Richard N. Pierson III, MD Division of Cardiac Surgery, University of Maryland Medical Center, 22 S. Greene Street, Baltimore, MD 21201, USA (E-mail: [email protected])Search for more papers by this author
First published: 05 July 2014
Citations: 16

Abstract

Xenotransplantation has undergone important progress in controlling initial hyperacute rejection in many preclinical models, with some cell, tissue, and organ xenografts advancing toward clinical trials. However, acute injury, driven primarily by innate immune and inflammatory responses, continues to limit results in lung xenograft models. The purpose of this article is to review the current status of lung xenotransplantation—including the seemingly unique challenges posed by this organ—and summarize proven and emerging means of overcoming acute lung xenograft injury.

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