Functional recovery in human partial thickness skin wounds after application of multicomponent hydrolipidic film (MAS063DP): A prospective, open-label, comparative clinical trial
Erh-Ti Lin MD
Department of Education, China Medical University Hospital, Taichung, Taiwan, Republic of China
Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorBor-Shyh Lin PhD
Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan, Taiwan, Republic of China
Search for more papers by this authorLi-Cheng Tsai MD
Department of Education, China Medical University Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorWei-Kung Chen MD
Department of Emergency, China Medical University Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorYen-Jen Wang MD
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
Search for more papers by this authorHsiu-Mei Chiang PhD
Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung, Taiwan, Republic of China
Search for more papers by this authorCorresponding Author
Chang-Cheng Chang MD, PhD
Aesthetic Medical Center, China Medical University Hospital, Taichung, Taiwan, Republic of China
Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan, Taiwan, Republic of China
Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung, Taiwan, Republic of China
Correspondence
Chang-Cheng Chang, Aesthetic Medical Center, China Medical University Hospital, Taichung, Taiwan, Republic of China
Email: [email protected]
Search for more papers by this authorErh-Ti Lin MD
Department of Education, China Medical University Hospital, Taichung, Taiwan, Republic of China
Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorBor-Shyh Lin PhD
Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan, Taiwan, Republic of China
Search for more papers by this authorLi-Cheng Tsai MD
Department of Education, China Medical University Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorWei-Kung Chen MD
Department of Emergency, China Medical University Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorYen-Jen Wang MD
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China
Search for more papers by this authorHsiu-Mei Chiang PhD
Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung, Taiwan, Republic of China
Search for more papers by this authorCorresponding Author
Chang-Cheng Chang MD, PhD
Aesthetic Medical Center, China Medical University Hospital, Taichung, Taiwan, Republic of China
Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan, Taiwan, Republic of China
Department of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung, Taiwan, Republic of China
Correspondence
Chang-Cheng Chang, Aesthetic Medical Center, China Medical University Hospital, Taichung, Taiwan, Republic of China
Email: [email protected]
Search for more papers by this authorFunding information: China Medical University, Grant/Award Number: CMU106-ASIA-20; Menarini Asia-Pacific Holdings PTE LTD, Grant/Award Number: 10642692
Abstract
Acute and minor skin wounds are common in daily life. However, in clinical practice, after initial management in the acute phase, the wounds are managed mainly through observation, and the patients are usually lost to follow-up. Considering a multicomponent hydrolipidic dressing (MAS063DP) long-known for its safe application in eczema and recently in laser-induced wounds, we aimed to evaluate its ability in functional recovery of impaired skin integrity during wound healing. Sixteen patients (N = 16) were enrolled and completed (n = 8 vs n = 8) this prospective, open-label, vehicle-controlled clinical trial with 12-week follow-up. Transepidermal water, skin viscoelasticity and bioimpedance analysis were measured initially, at the 1st, 4th, 8th, and 12th weeks. Improvements in these parameters were greater in the MAS063DP group (from 31.4 ± 9.0 to 16.4 ± 4.3 g/m2 h, P < .001; from 77 ± 16% to 88 ± 9%, P < .05; from 4182 ± 3823 to 2644 ± 1772 Ω) than in the white petrolatum group. No significant adverse events occurred, and all participants were more satisfied with the intervention. In this study, MAS063DP can restore skin integrity and reinstitute physiologic function as a feasible and safe intervention more markedly than management through observation during the healing process by providing protective hydrolipidic layer on the skin with simultaneous anti-inflammatory and antioxidant activities from its key ingredients such as glycyrrhetinic acid, Vitis vinifera, telmesteine, and vitamins C and E.
CONFLICT OF INTEREST
The authors declare no conflicts of interest relevant to the reported work.
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