Short- and long-term outcomes of arterial reconstruction on recipient splenic artery in adult liver transplantation. Single-center prospective study 25 years after first description
Corresponding Author
Laura Llado
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Correspondence
Laura Llado PhD, Liver Transplant Unit, Hospital Universitari de Bellvitge, 08907 Barcelona, Spain.
Tel.: (+34) 93 260 7940;
fax: (+34) 93 260 7603;
e-mail: [email protected]
Search for more papers by this authorEmilio Ramos
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorAlex Bravo
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorCarme Baliellas
Liver Transplant Unit, Department of Gastroenterology, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorKristel Mils
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorJuli Busquets
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorAlba Cachero
Liver Transplant Unit, Department of Gastroenterology, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorLluis Secanella
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorNuria Pelaez
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorEmma Gonzalez-Vilatarsana
Liver Transplant Unit, Department of Clinical Nurse Specialist, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorJoan Fabregat
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorCorresponding Author
Laura Llado
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Correspondence
Laura Llado PhD, Liver Transplant Unit, Hospital Universitari de Bellvitge, 08907 Barcelona, Spain.
Tel.: (+34) 93 260 7940;
fax: (+34) 93 260 7603;
e-mail: [email protected]
Search for more papers by this authorEmilio Ramos
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorAlex Bravo
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorCarme Baliellas
Liver Transplant Unit, Department of Gastroenterology, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorKristel Mils
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorJuli Busquets
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorAlba Cachero
Liver Transplant Unit, Department of Gastroenterology, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorLluis Secanella
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorNuria Pelaez
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorEmma Gonzalez-Vilatarsana
Liver Transplant Unit, Department of Clinical Nurse Specialist, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorJoan Fabregat
Liver Transplant Unit, Department of Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
Search for more papers by this authorSummary
Several techniques have been proposed for liver transplantation with inadequate hepatic artery (HA) anastomosis. We aimed to analyze outcomes of arterial reconstruction with the splenic artery (SA). This was a prospective study of our experience with recipients who underwent arterial anastomosis on the SA compared with patients who underwent standard HA. We included 54 patients in the SA group and 1405 in the HA group. Patients in SA group were more frequently retransplantation (31% vs. 8%; P = 0.001), required more transfusion (11 ± 12 vs. 6 ± 9.9 PRC; P = 0.001), had longer surgeries (424 ± 95 vs. 394 ± 102 min; P = 0.03), and longer hospital stays (28 ± 29 vs. 20 ± 18 days; P = 0.002). There were no differences in vascular and biliary complications (15% and 7%; P = 0.18; and 32% and 23%; P = 0.32), primary dysfunction (11% and 9%; P = 0.74), reoperation (12% and 10%; P = 0.61), postoperative mortality (13% and 7%; P = 0.12) and 5 years survival (66% vs. 63%; P = 0.71). Following primary transplantation, there were no differences. The outcomes of arterial reconstruction using the recipients' SA in adult liver transplantation are comparable to those for standard HA reconstruction after a first transplant.
Conflict of interest
The authors have declared no conflict of interest.
References
- 1Silva MA, Jambulingam PS, Gunson BK, et al. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom. Liver Transpl 2006; 12: 146.
- 2Duffy JP, Hong JC, Farmer DG, et al. Vascular complications of orthotopic liver transplantation: experience in more than 4200 patients. J Am Coll Surg 2009; 208: 896.
- 3Bekker J, Ploem S, de Jong KP. Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risks factors. Am J Transplant 2009; 9: 746.
- 4Tzakis A, Todo S, Starzl TE. The anterior route for arterial graft conduits in liver transplantation. Transpl Int 1989; 2: 121.
- 5Shaked AA, Takiff H, Busuttil RW. The use of the supraceliac aorta for hepatic arterial revascularization in transplantation of the liver. Surg Gynecol Obstet 1991; 173: 198.
- 6Mueisan O, Rela M, Nodari F, et al. Use of infrarenal conduits for arterial revascularization in orthotopic liver transplantation. Liver Transpl 1998; 4: 232.
- 7Hibi T, Nishida S, Levi DM, et al. Long-term deleterious effects of aortohepatic conduits in primary liver transplantation: proceed with caution. Liver Transpl 2013; 19: 916.
- 8Chatzizacharias NA, Aly MA, Praseedom RK. The role of arterial conduits for revascularization in adult orthotopic liver transplantation. Transplant Rev 2017; 31: 121.
- 9Figueras J, Jaurrieta E, Segura R, et al. A simplified technique for hepatic revascularization of the liver graft with inadequate recipient hepatic artery. Transplant Int 1992; 5: 120.
- 10Figueras J, Parés D, Aranda H, et al. Results of using the recipients's splenic artery for arterial reconstruction in 23 patients. Transplantation 1997; 64: 655.
- 11Cherqui D, Riff Y, Rotman N, Julien M, Fagniez PL. The recipient splenic artery for arterializations in orthotopic liver transplantation. Am J Surg 1994; 167: 327.
- 12Vanderlan WB, Abouljoud MS, Yoshida A, Kim DY. Experience with recipient splenic artery inflow in adult liver transplantation: a case series. Cases J 2008; 1: 82.
- 13Katz E, Fukuzawa K, Schwartz M, Mor E, Miller C. The splenic artery as the inflow in arterial revascularization of the liver graft in clinical transplantation. Transplantation 1992; 53: 1373.
- 14Dokmak S, Aussilhou B, Landi F, et al. The recipient celiac trunk as an alternative to the native hepatic artery for arterial reconstruction in adult liver transplantation. Liver Transpl 2015; 21: 1133.
- 15Lladó L, Figueras J. Techniques of orthotopic liver transplantation. HPB 2004; 6: 69.
- 16Figueras J, Lladó L, Ramos E, et al. Temporary portocaval shunt during liver transplantation with vena cava preservation. Results of a prospective randomized study. Liver Transpl 2001; 7: 904.
- 17Yang Y, Zhao JC, Yan LN, et al. Risk factors associated with early and late HAT after adult liver transplantation. World J Gastroenterol 2014; 20: 10545.
- 18Oberkofler CE, Reese T, Raptis DA, et al. Hepatic artery occlusion in liver transplantation – what counts more: type of reconstruction or severity of recipient's disease? Liver Transpl 2018; 24: 790 in press.
- 19Herrero A, Souche R, Joly E, et al. Early hepatic artery thrombosis after liver transplantation: what is the impact of the arterial reconstruction type? World J Surg 2017; 41: 2101.
- 20Muralidharan V, Imber C, Leelaudomlipi S, et al. Arterial conduits for hepatic artery revascularization in adult liver transplantation. Transpl Int 2004; 17: 163.
- 21Reese T, Raptis DA, Oberkofler CE, et al. A systematic review and meta-analysis of rescue revascularization with arterial conduits in liver transplantation. Am J Transplant 2019; 19: 551 in press.
- 22Kazemi K, Damidoost P, Deilami N, et al. A new consideration in hepatic artery reconstruction in adult liver transplant: arterial transposition versus extra-anatomic jump grafts. Exp Clin Transplant 2017; 15 (Suppl. 1): 204.
- 23Schwalke MA, Crowley JP, Spencer P, Metzger J, Kawan M, Burchard KW. Splenic artery ligation for splenic salvage: clinical experience and immune function. J Trauma 1991; 31: 385.
- 24El-Hinnawi A, Nishida S, Levi DM, et al. Use of the recipient celiac trunk for hepatic reconstruction in orthotopic liver transplantation. Transplant Proc 2013; 45: 1928.