Addressing uncertainties in renal transplantation: hypomagnesemia and the case of diabetes prevention
Corresponding Author
Johannes M. Werzowa
Clinical Division of Nephrology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Correspondence
Johannes M. Werzowa, Clinical Division of Nephrology, Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Tel.: +431 40400 43910;
fax: +431 40400 43920;
e-mail: [email protected]
Search for more papers by this authorMarcus D. Säemann
Clinical Division of Nephrology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Search for more papers by this authorCorresponding Author
Johannes M. Werzowa
Clinical Division of Nephrology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Correspondence
Johannes M. Werzowa, Clinical Division of Nephrology, Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Tel.: +431 40400 43910;
fax: +431 40400 43920;
e-mail: [email protected]
Search for more papers by this authorMarcus D. Säemann
Clinical Division of Nephrology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Search for more papers by this authorConflicts of interest:
The authors have declared no conflicts of interest.
References
- 1Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J Endocrinol Metab 2012; 16: 1000.
- 2Fox C, Ramsoomair D, Carter C. Magnesium: its proven and potential clinical significance. South Med J 2001; 94: 1195.
- 3Hruby A, Ngwa JS, Renstrom F, et al. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr 2013; 143: 345.
- 4Sakaguchi Y, Shoji T, Hayashi T, et al. Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease. Diabetes Care 2012; 35: 1591.
- 5Del Gobbo LC, Imamura F, Wu JH, de Oliveira Otto MC, Chiuve SE, Mozaffarian D. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 2013; 98: 160.
- 6Sakaguchi Y, Fujii N, Shoji T, Hayashi T, Rakugi H, Isaka Y. Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis. Kidney Int 2014; 85: 174.
- 7Rodriguez-Ortiz ME, Canalejo A, Herencia C, et al. Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration. Nephrol Dial Transplant 2014; 29: 282.
- 8Gunther T. The biochemical function of Mg(2)+ in insulin secretion, insulin signal transduction and insulin resistance. Magnes Res 2010; 23: 5.
- 9Osorio JM, Bravo J, Perez A, Ferreyra C, Osuna A. Magnesemia in renal transplant recipients: relation with immunosuppression and posttransplant diabetes. Transpl Proc 2010; 42: 2910.
- 10Augusto JF, Subra JF, Duveau A, et al. Relation between pretransplant magnesemia and the risk of new onset diabetes after transplantation within the first year of kidney transplantation. Transplantation 2014; 97: 1155.
- 11Van Laecke S, Desideri F, Geerts A, et al. Hypomagnesemia and the risk of new-onset diabetes after liver transplantation. Liver Transpl 2010; 16: 1278.
- 12Van Laecke S, Van Biesen W, Verbeke F, De Bacquer D, Peeters P, Vanholder R. Posttransplantation hypomagnesemia and its relation with immunosuppression as predictors of new-onset diabetes after transplantation. Am J Transplant 2009; 9: 2140.
- 13Nijenhuis T, Hoenderop JG, Bindels RJ. Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia. J Am Soc Nephrol 2004; 15: 549.
- 14Santos L, Rodrigo E, Pinera C, et al. Elevated serum gamma-glutamyltransferase and hypomagnesemia are not related with new-onset diabetes after transplantation. Transpl Proc 2010; 42: 2914.
- 15Van Laecke S, Nagler EV, Taes Y, Biesen WV, Peeters P, Vanholder R. The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial. Transplant Int 2014; 27.
- 16Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res 2003; 16: 183.
- 17Nair AV, Hocher B, Verkaart S, et al. Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy. Proc Natl Acad Sci U S A 2012; 109: 11324.
