LETTER TO THE EDITOR
The senescent antigen hypothesis of RBC evanescence: 50 years of correlation without causation
James C. Zimring,
Corresponding Author
James C. Zimring
Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
Correspondence
James C. Zimring, University of Virginia School of Medicine, P.O. Box 801386, Charlottesville, VA 22908, USA.
Email: [email protected]
Search for more papers by this author Steven L. Spitalnik,
Steven L. Spitalnik
Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA
Search for more papers by this author Krystalyn E. Hudson,
Krystalyn E. Hudson
Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA
Search for more papers by this author
James C. Zimring,
Corresponding Author
James C. Zimring
Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
Correspondence
James C. Zimring, University of Virginia School of Medicine, P.O. Box 801386, Charlottesville, VA 22908, USA.
Email: [email protected]
Search for more papers by this author Steven L. Spitalnik,
Steven L. Spitalnik
Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA
Search for more papers by this author Krystalyn E. Hudson,
Krystalyn E. Hudson
Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA
Search for more papers by this author
First published: 08 November 2022
No abstract is available for this article.
REFERENCES
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- 2Badior KE, Casey JR. Large conformational dynamics in band 3 protein: significance for erythrocyte senescence signalling. Biochim Biophys Acta Biomembr. 2021; 1863:183678.
- 3Singer JA, Jennings LK, Jackson CW, Dockter ME, Morrison M, Walker WS. Erythrocyte homeostasis: antibody-mediated recognition of the senescent state by macrophages. Proc Natl Acad Sci U S A. 1986; 83: 5498–501.
- 4Christian JA, Rebar AH, Boon GD, Low PS. Senescence of canine biotinylated erythrocytes: increased autologous immunoglobulin binding occurs on erythrocytes aged in vivo for 104 to 110 days. Blood. 1993; 82: 3469–73.
- 5Hudson KE, de Wolski K, Kapp LM, Richards AL, Schniederjan MJ, Zimring JC. Antibodies to senescent antigen and C3 are not required for Normal red blood cell lifespan in a murine model. Front Immunol. 2017; 8: 1425.
