ORIGINAL ARTICLE
High-resolution quantitative acoustic microscopy of cutaneous carcinoma and melanoma: Comparison with histology
Sarah Youssef, Inna Seviaryna,
David Shum, Elena Maeva, Eugene Malyarenko,
Naila Rahman, Roman Gr. Maev,
Corresponding Author
Inna Seviaryna
University of Windsor, Windsor, Ontario
Correspondence
Inna Seviaryna, University of Windsor, Windsor, ON.
Email: [email protected]
Search for more papers by this authorEugene Malyarenko
Sonamed Technologies LLC, Birmingham, Michigan
Search for more papers by this authorSarah Youssef, Inna Seviaryna,
David Shum, Elena Maeva, Eugene Malyarenko,
Naila Rahman, Roman Gr. Maev,
Corresponding Author
Inna Seviaryna
University of Windsor, Windsor, Ontario
Correspondence
Inna Seviaryna, University of Windsor, Windsor, ON.
Email: [email protected]
Search for more papers by this authorEugene Malyarenko
Sonamed Technologies LLC, Birmingham, Michigan
Search for more papers by this authorAbstract
Background
The increased incidence rate of skin cancers during the last decades is alarming. One of the significant difficulties in the histopathology of skin cancers is appearance variability due to the heterogeneity of diseases or tissue preparation and staining process. This study aims to investigate whether the high-resolution acoustic microscopy has the potential for identifying and quantitatively classifying skin cancers.
Material/Methods
Unstained standard formalin-fixed skin tissue samples were used for ultrasonic examination. The high-frequency acoustic microscope equipped with the 320 MHz transducer was utilized to visualize skin structure. Fourier transform was performed to calculate the sound speed and attenuation in the tissue.
Results
The acoustic images demonstrate good concordance with the traditional histology images. All histological features in the tumour were easily identifiable on acoustic images. Each skin cancer type has its combination of ultrasonic properties significantly different from the healthy skin.
Conclusions
High-resolution acoustic imaging strengthened with quantitative analysis shows a potential to work as an auxiliary imaging modality assisting pathologists to lean to the particular decision in doubtful cases. The method can also assist surgeon to ensure the complete resection of a tumour.
CONFLICT OF INTEREST
The authors have declared that there is no conflict of interest.
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