Long-Term High-Intensity Interval Training Intervention Improves Emotional Conflict Control in Association With Right Ventrolateral Prefrontal Activation in Males With Methamphetamine Use Disorder: A Randomized Controlled Trial
Meiheng He
School of Psychology, Northwest Normal University, Lanzhou, China
School of Psychology, Shanghai University of Sport, Shanghai, China
Search for more papers by this authorLili Wang
School of Educational Science, Huaiyin Normal University, Huaian, China
Search for more papers by this authorDing Xu
Shanghai Bureau of Drug Rehabilitation Administration, Shanghai, China
Search for more papers by this authorYing Liu
School of Psychology, Shanghai University of Sport, Shanghai, China
Search for more papers by this authorXiangru Zhu
Institute of Cognition, Brain and Health, Henan University, Kaifeng, China
Search for more papers by this authorCorresponding Author
Dong Zhu
School of Wushu, Shanghai University of Sport, Shanghai, China
Correspondence:
Dong Zhu ([email protected])
Suyong Yang ([email protected])
Search for more papers by this authorCorresponding Author
Suyong Yang
School of Psychology, Shanghai University of Sport, Shanghai, China
Correspondence:
Dong Zhu ([email protected])
Suyong Yang ([email protected])
Search for more papers by this authorMeiheng He
School of Psychology, Northwest Normal University, Lanzhou, China
School of Psychology, Shanghai University of Sport, Shanghai, China
Search for more papers by this authorLili Wang
School of Educational Science, Huaiyin Normal University, Huaian, China
Search for more papers by this authorDing Xu
Shanghai Bureau of Drug Rehabilitation Administration, Shanghai, China
Search for more papers by this authorYing Liu
School of Psychology, Shanghai University of Sport, Shanghai, China
Search for more papers by this authorXiangru Zhu
Institute of Cognition, Brain and Health, Henan University, Kaifeng, China
Search for more papers by this authorCorresponding Author
Dong Zhu
School of Wushu, Shanghai University of Sport, Shanghai, China
Correspondence:
Dong Zhu ([email protected])
Suyong Yang ([email protected])
Search for more papers by this authorCorresponding Author
Suyong Yang
School of Psychology, Shanghai University of Sport, Shanghai, China
Correspondence:
Dong Zhu ([email protected])
Suyong Yang ([email protected])
Search for more papers by this authorFunding: This study was funded by the Shanghai Bureau of Drug Rehabilitation Administration under Grant (SF201920107) and the Nature Science Foundation of JiangSu Province (BK20191485).
ABSTRACT
Acute high-intensity interval training (HIIT) has cognitive benefits in individuals with methamphetamine use disorder (MUD), yet it remains largely unknown the benefits of long-term HIIT on emotional conflict control and its neural mechanism in individuals with MUD. The current study conducted a 36-week low-volume HIIT intervention to investigate the effects of HIIT on emotional conflict control in males with MUD and their prefrontal cortex (PFC) activation. This study was a sub-study of the Study for Rehabilitation Training Model Construction and Training Effect of High Intensity Compound Exercise Prescription. Forty males with MUD (31.50 ± 4.33 years) were randomly assigned to the HIIT group and control group. The HIIT group received a 36-week low-volume HIIT intervention, while the control group maintained daily physical exercise. The emotional conflict task (emotional face-word Stroop task) with functional near-infrared spectroscopy (fNIRS) recording and subjective craving test were performed before and after the intervention. The results showed that the HIIT intervention reduced the emotional conflict and increased cortical activations of right dorsolateral PFC (dlPFC) and right ventrolateral PFC (vlPFC). More importantly, the HIIT-induced decreased emotional conflict was associated significantly with increased right vlPFC activation. In addition, subjective craving was also reduced after HIIT intervention. While the control group showed significant changes in neither brain activation nor the craving. These findings suggest that long-term low-volume HIIT can improve PFC activation, promote emotional conflict control, and reduce subjective craving in males with MUD. HIIT seems to be an effective method of withdrawal rehabilitation for males with MUD.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that supports the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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