Original Article
Investigating the age-related “anterior shift” in the scalp distribution of the P3b component using principal component analysis
Brittany R. Alperin,
Katherine K. Mott,
Dorene M. Rentz,
Phillip J. Holcomb,
Kirk R. Daffner,
Brittany R. Alperin
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorKatherine K. Mott
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorDorene M. Rentz
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorPhillip J. Holcomb
Department of Psychology, Tufts University, Medford, Massachusetts, USA
Search for more papers by this authorCorresponding Author
Kirk R. Daffner
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Address correspondence to: Kirk R. Daffner, MD, FAAN, Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. E-mail: [email protected]Search for more papers by this authorBrittany R. Alperin,
Katherine K. Mott,
Dorene M. Rentz,
Phillip J. Holcomb,
Kirk R. Daffner,
Brittany R. Alperin
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorKatherine K. Mott
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorDorene M. Rentz
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorPhillip J. Holcomb
Department of Psychology, Tufts University, Medford, Massachusetts, USA
Search for more papers by this authorCorresponding Author
Kirk R. Daffner
Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham, Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Address correspondence to: Kirk R. Daffner, MD, FAAN, Center for Brain/Mind Medicine, Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. E-mail: [email protected]Search for more papers by this authorThis research was funded in part by NIA grant R01 AGO17935 and by generous support from the Wimberly family, the Muss family, and the Mortimer/Grubman family. The authors would like to thank Christine Dunant for her excellent administrative assistance and Dr. Joseph Dien for his patient guidance in troubleshooting the PCA toolkit.
Abstract
An age-related “anterior shift” in the distribution of the P3b is often reported. Temporospatial principal component analysis (PCA) was used to investigate the basis of this observation. ERPs were measured in young and old adults during a visual oddball task. PCA revealed two spatially distinct factors in both age groups, identified as the posterior P3b and anterior P3a. Young subjects generated a smaller P3a than P3b, while old subjects generated a P3a that did not differ in amplitude from their P3b. Rather than having a more anteriorly distributed P3b, old subjects produced a large, temporally overlapping P3a. The pattern of the age-related “anterior shift” in the P3 was similar for target and standard stimuli. The increase in the P3a in elderly adults may not represent a failure to habituate the novelty response, but may reflect greater reliance on executive control operations (P3a) to carry out the categorization/updating process (P3b).
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