Predictive Value of Prospective Memory for Remission in First-Episode Schizophrenia
Fu-Chun Zhou MD, PhD
Attending Psychiatrist
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorCorresponding Author
Yu-Tao Xiang MD, PhD
Adjunct Associate Director, Research Assistant Professor
Mood Disorders Centre, Beijing Anding Hospital, Capital Medical University, Beijing, China
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Author contact:
[email protected], with a copy to the Editor: [email protected]
Search for more papers by this authorChuan-Yue Wang MD, PhD
Professor
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorFaith Dickerson PhD
Director
The Stanley Research Program at Sheppard Pratt, Baltimore, Maryland, USA
Search for more papers by this authorJulie Kreyenbuhl PharmD, PhD
Associate Director, Associate Professor
Research Core, Veterans Administration Capitol Healthcare Network (VISN 5) Mental Illness Research, Education, and Clinical Center (MIRECC)
Division of Services Research, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
Search for more papers by this authorGabor S. Ungvari MD, PhD
Professor
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
University of Notre Dame Australia/Marian Centre, Perth, Western Australia, Australia
Search for more papers by this authorRaymond W. C. Au PhD
Occupational Therapist
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorJing-Jing Zhou MPhil
Resident Psychiatrist
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorYan Zhou BA
Research Nurse
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorDavid Shum PhD
Professor
School of Applied Psychology and Griffith Health Institute, Griffith University, Brisbane, Queensland, Australia
Search for more papers by this authorDavid Man PhD
Professor
Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong SAR, China
Search for more papers by this authorKelly Y. C. Lai MRCPsy
Associate Professor
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorWai-Kwong Tang MRCPsy
Professor
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorXin Yu MD
Professor
Peking University Institute of Mental Health, Beijing, China
Search for more papers by this authorHelen F. K. Chiu FRCPsy
Professor
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorFu-Chun Zhou MD, PhD
Attending Psychiatrist
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorCorresponding Author
Yu-Tao Xiang MD, PhD
Adjunct Associate Director, Research Assistant Professor
Mood Disorders Centre, Beijing Anding Hospital, Capital Medical University, Beijing, China
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Author contact:
[email protected], with a copy to the Editor: [email protected]
Search for more papers by this authorChuan-Yue Wang MD, PhD
Professor
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorFaith Dickerson PhD
Director
The Stanley Research Program at Sheppard Pratt, Baltimore, Maryland, USA
Search for more papers by this authorJulie Kreyenbuhl PharmD, PhD
Associate Director, Associate Professor
Research Core, Veterans Administration Capitol Healthcare Network (VISN 5) Mental Illness Research, Education, and Clinical Center (MIRECC)
Division of Services Research, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
Search for more papers by this authorGabor S. Ungvari MD, PhD
Professor
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
University of Notre Dame Australia/Marian Centre, Perth, Western Australia, Australia
Search for more papers by this authorRaymond W. C. Au PhD
Occupational Therapist
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorJing-Jing Zhou MPhil
Resident Psychiatrist
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorYan Zhou BA
Research Nurse
Beijing Anding Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorDavid Shum PhD
Professor
School of Applied Psychology and Griffith Health Institute, Griffith University, Brisbane, Queensland, Australia
Search for more papers by this authorDavid Man PhD
Professor
Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong SAR, China
Search for more papers by this authorKelly Y. C. Lai MRCPsy
Associate Professor
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorWai-Kwong Tang MRCPsy
Professor
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorXin Yu MD
Professor
Peking University Institute of Mental Health, Beijing, China
Search for more papers by this authorHelen F. K. Chiu FRCPsy
Professor
Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorConflict of Interest Statement:
There is no conflict of interest concerning the authors in conducting this study and preparing the manuscript.
Abstract
Purpose
The study examined the rate of remission in individuals experiencing a first episode of schizophrenia (FES) in China and explored predictors of remission in the acute phase of the illness.
Design and Methods
Fifty-five FES patients were randomly treated with risperidone, olanzapine, or aripiprazole at therapeutic doses for 8 weeks, and their clinical profiles and cognition were assessed using standardized assessment instruments at entry and the end of the study.
Findings
Of the 55 patients, 30 (54.5%) remitted by the end of the 8-week study. In univariate analyses, shorter duration of untreated psychosis, higher scores on both the time-based prospective memory (TBPM) and event-based prospective memory tasks and the Hopkins Verbal Learning Test-revised, and less severe negative symptoms were significantly associated with remission. In stepwise multiple logistic regression analyses, only higher scores on the TBPM significantly predicted remission. Individuals having higher scores reflecting better TBPM at baseline were more likely to achieve remission after 8 weeks of optimized antipsychotic treatment.
Practice Implications
TPBM may be useful in helping clinicians identify those FES patients most likely to achieve a favorable treatment response.
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