Review of the impact of donor characteristics on pediatric heart transplant outcomes
Correction(s) for this article
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Erratum
- Volume 25Issue 7Pediatric Transplantation
- First Published online: July 3, 2021
Corresponding Author
Jennifer Conway
Division of Pediatric Cardiology, Department of Pediatrics, Stollery Children’s Hospital, University of Alberta, Edmonton, AB, Canada
Correspondence
Jennifer Conway, 8440 112 Street, WMC 4C2, Edmonton, AB T6G2B7, Canada.
Email: [email protected]
Search for more papers by this authorJean A. Ballweg
Division of Pediatric Cardiology, Department of Pediatrics, Children’s Hospital and Medical Center, University of Nebraska Medical Center, Omaha, Nebraska
Search for more papers by this authorMatthew Fenton
Great Ormond Street Hospital for Children Foundation Trust, London, UK
Search for more papers by this authorSteve Kindel
Division of Pediatric Cardiology, Department of Pediatrics, Medical College of Wisconsin and Herma Heart Institute and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorMaryanne Chrisant
The Heart Institute, Joe Dimaggio Children’s Hospital, Hollywood, Florida
Search for more papers by this authorRobert G. Weintraub
Department of Paediatrics, The University of Melbourne, Melbourne, Vic, Australia
Department of Cardiology, The Royal Children's Hospital, Melbourne Heart Research Group, Murdoch Children’s Research Institute, Melbourne, Vic, Australia
Search for more papers by this authorLara Danziger-Isakov
Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center & University of Cincinnati, Cincinnati, Ohio
Search for more papers by this authorRichard Kirk
Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas
Search for more papers by this authorOliver Miera
Department of Congenital Heart Disease/Pediatric Cardiology, Berlin, Germany
Search for more papers by this authorRyan R. Davies
Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas
Search for more papers by this authorAnne I. Dipchand
Labatt Family Heart Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Search for more papers by this authorCorresponding Author
Jennifer Conway
Division of Pediatric Cardiology, Department of Pediatrics, Stollery Children’s Hospital, University of Alberta, Edmonton, AB, Canada
Correspondence
Jennifer Conway, 8440 112 Street, WMC 4C2, Edmonton, AB T6G2B7, Canada.
Email: [email protected]
Search for more papers by this authorJean A. Ballweg
Division of Pediatric Cardiology, Department of Pediatrics, Children’s Hospital and Medical Center, University of Nebraska Medical Center, Omaha, Nebraska
Search for more papers by this authorMatthew Fenton
Great Ormond Street Hospital for Children Foundation Trust, London, UK
Search for more papers by this authorSteve Kindel
Division of Pediatric Cardiology, Department of Pediatrics, Medical College of Wisconsin and Herma Heart Institute and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Search for more papers by this authorMaryanne Chrisant
The Heart Institute, Joe Dimaggio Children’s Hospital, Hollywood, Florida
Search for more papers by this authorRobert G. Weintraub
Department of Paediatrics, The University of Melbourne, Melbourne, Vic, Australia
Department of Cardiology, The Royal Children's Hospital, Melbourne Heart Research Group, Murdoch Children’s Research Institute, Melbourne, Vic, Australia
Search for more papers by this authorLara Danziger-Isakov
Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center & University of Cincinnati, Cincinnati, Ohio
Search for more papers by this authorRichard Kirk
Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas
Search for more papers by this authorOliver Miera
Department of Congenital Heart Disease/Pediatric Cardiology, Berlin, Germany
Search for more papers by this authorRyan R. Davies
Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas
Search for more papers by this authorAnne I. Dipchand
Labatt Family Heart Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Search for more papers by this author[Correction added on June 28, 2021 after first online publication: the name of the ninth author was changed from “Oliver Meira” to “Oliver Miera”.]
Abstract
Heart transplantation (HTx) is a treatment option for end-stage heart failure in children. HTx is limited by the availability and acceptability of donor hearts. Refusal of donor hearts has been reported to be common with reasons for refusal including preexisting donor characteristics. This review will focus on the impact of donor characteristics and comorbidities on outcomes following pediatric HTx. A literature review was performed to identify articles on donor characteristics and comorbidities and pediatric HTx outcomes. There are many donor characteristics to consider when accepting a donor heart. Weight-based matching is the most common form of matching in pediatric HTx with a donor-recipient weight ratio between 0.7 and 3 having limited impact on outcomes. From an age perspective, donors <50 years can be carefully considered, but the impact of ischemic time needs to be understood. To increase the donor pool, with minimal impact on outcomes, ABO-incompatible donors should be considered in patients that are eligible. Other factors to be considered when accepting an organ is donor comorbidities. Little is known about donor comorbidities in pediatric HTx, with most of the data available focusing on infections. Being aware of the potential infections in the donor, understanding the testing available and risks of transmission, and treatment options for the recipient is essential. There are a number of donor characteristics that potentially impact outcomes following pediatric HTx, but these need to be taken into consideration along with their interactions with recipient factors when interpreting the outcomes following HTx.
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