Case Report

Spectrum of Clinical Responses to Therapies in Infantile Bullous Pemphigoid

Corresponding Author

Hélène Taquin M.D.

Department of Dermatology, University Hospital of Nice, Nice, France

Address correspondence to Hélène Taquin, M.D., Department of Dermatology, University Hospital of Nice, Archet 2 Hospital, Route de Saint Antoine de Ginestière, 06200 Nice, France, or e-mail: [email protected].Search for more papers by this author

Christine Chiaverini M.D., Ph.D.,

Christine Chiaverini M.D., Ph.D.

Department of Dermatology, University Hospital of Nice, Nice, France

Department of Pediatrics, Nice Centre Hospitalier Universitaire Lenval Pediatric Hospital, Nice, France

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Jean Philippe Lacour M.D.,

Jean Philippe Lacour M.D.

Department of Dermatology, University Hospital of Nice, Nice, France

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Hélène Taquin M.D.,

Corresponding Author

Hélène Taquin M.D.

Department of Dermatology, University Hospital of Nice, Nice, France

Christine Chiaverini M.D., Ph.D.,

Christine Chiaverini M.D., Ph.D.

Department of Dermatology, University Hospital of Nice, Nice, France

Department of Pediatrics, Nice Centre Hospitalier Universitaire Lenval Pediatric Hospital, Nice, France

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Jean Philippe Lacour M.D.,

Jean Philippe Lacour M.D.

Department of Dermatology, University Hospital of Nice, Nice, France

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First published: 14 January 2016

https://doi.org/10.1111/pde.12779

Citations: 8

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Abstract

Infantile bullous pemphigoid (BP) is a rare autoimmune dermatosis characterized by the presence of antibodies against basal membrane zone proteins. Histologic and immunologic features are similar to those of the adult disease, but its clinical features may vary in children. We report here four cases of infantile BP whose atypical presentation or progression shed new light on the disease.

References

1Waisbourd-Zinman O, Ben-Amitai D, Cohen AD et al. Bullous pemphigoid in infancy: clinical and epidemiologic characteristics. J Am Acad Dermatol 2008; 58: 41–48.
10.1016/j.jaad.2007.08.010
PubMed Web of Science® Google Scholar
2Merida C, Martinez-Escriban JA, Frias JF et al. Bullous pemphigoid in an infant after vaccination. Actas Dermosifiliogr 2005; 96: 255–257.
10.1016/S0001-7310(05)73081-7
PubMed Google Scholar
3Fisler RE, Saeb M, Liang MG et al. Childhood bullous pemphigoid: a clinicopathologic study and review of the literature. Am J Dermatopathol 2003; 25: 183–189.
10.1097/00000372-200306000-00001
PubMed Web of Science® Google Scholar
4Izumi H, Hosokawa H. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 1986; 136: 1231–1235.
PubMed Web of Science® Google Scholar
5Chiaverini C, Hamel-Teillac D, Gilbert D et al. Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid. Br J Dermatol 2006; 154: 839–843.
10.1111/j.1365-2133.2005.07061.x
CAS PubMed Web of Science® Google Scholar
6Chimanovitch I, Hamm H, Georgi M et al. Bullous pemphigoid of childhood: autoantibodies target the same epitopes within the NC16A domain of BP180 as autoantibodies in bullous pemphigoid of adulthood. Arch Dermatol 2000; 136: 527–532.
10.1001/archderm.136.4.527
CAS PubMed Web of Science® Google Scholar
7Nemeth AJ, Klein AD, Gould EW et al. Childhood bullous pemphigoid: clinical and immunologic features, treatment and prognosis. Arch Dermatol 1991; 127: 378–386.
PubMed Web of Science® Google Scholar
8de la Fuente S, Hernández-Martín Á, de Lucas R et al. Postvaccination bullous pemphigoid in infancy: report of three new cases and literature review. Pediatr Dermatol 2013; 30: 741–744.
10.1111/pde.12231
PubMed Web of Science® Google Scholar
9Al-Mutairi N, Sharma AK, Zaki A et al. Maternal and neonatal pemphigoid gestationis. Clin Exp Dermatol 2004; 29: 202–204.
10.1111/j.1365-2230.2004.01481.x
CAS PubMed Web of Science® Google Scholar
10Toyama T, Nakamura K, Kuramochi A et al. Two cases of childhood bullous pemphigoid. Eur J Dermatol 2009; 19: 368–371.
10.1684/ejd.2009.0694
PubMed Web of Science® Google Scholar
11Singalavanija S, Limpongsanurak W. Immunobullous diseases in Thai children: report of 24 cases. J Med Assoc Thai 2003; 86: 681–688.
PubMed Google Scholar
12Nobuyuki S, Yayoi N, Yoichiro M et al. Infantile bullous pemphigoid treated with intravenous immunoglobulin therapy. J Am Acad Dermatol 2007; 57: 1084–1089.
10.1016/j.jaad.2007.08.005
PubMed Web of Science® Google Scholar
13Marcus KA, Halbertsma FJ, Van Steensel MA. A case of juvenile bullous pemphigoid—successful treatment with diaminodiphenylsulfone and prednisone. Pediatr Dermatol 2009; 26: 55–58.
10.1111/j.1525-1470.2008.00822.x
PubMed Web of Science® Google Scholar
14Schwieger-Briel A, Moellmann C, Mattulat B et al. Bullous pemphigoid in infants: characteristics, diagnosis and treatment. Orphanet J Rare Dis 2014; 9: 185.
10.1186/s13023-014-0185-6
PubMed Web of Science® Google Scholar
15Xiao T, Li B, Wang Y et al. Childhood bullous pemphigoid treated by i.v. immunoglobulin. J Dermatol 2007; 34: 650–653.
10.1111/j.1346-8138.2007.00348.x
CAS PubMed Web of Science® Google Scholar

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Volume33, Issue2

March/April 2016

Pages e77-e81

Spectrum of Clinical Responses to Therapies in Infantile Bullous Pemphigoid

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Spectrum of Clinical Responses to Therapies in Infantile Bullous Pemphigoid

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