Increases in plasma IgG4/IgE with trilipid vs paraffin/petrolatum-based emollients for dry skin/eczema
Sayantani Sindher
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorShifaa S. Alkotob
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorMelanie N. Shojinaga
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorRobert Hamilton
Divisions of Allergy and Clinical Immunology, Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Search for more papers by this authorSusan Chan
Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, St. Thomas’ Hospital, King’s College London, London, UK
Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St.Thomas’ Hospital NHS Foundation Trust, London, UK
Paediatric Allergy Group, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Guys’ Hospital, King’s College London, London, UK
Search for more papers by this authorShu Cao
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorHenry T. Bahnson
Benaroya Research Institute and Immune Tolerance Network, Seattle, WA, USA
Search for more papers by this authorHelen A. Brough
Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, St. Thomas’ Hospital, King’s College London, London, UK
Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St.Thomas’ Hospital NHS Foundation Trust, London, UK
Paediatric Allergy Group, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Guys’ Hospital, King’s College London, London, UK
Search for more papers by this authorGideon Lack
Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, St. Thomas’ Hospital, King’s College London, London, UK
Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St.Thomas’ Hospital NHS Foundation Trust, London, UK
Paediatric Allergy Group, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Guys’ Hospital, King’s College London, London, UK
Search for more papers by this authorDonald Y. M. Leung
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO, USA
Search for more papers by this authorCorresponding Author
Kari C. Nadeau
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Division of Allergy, Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA
Correspondence
Kari C. Nadeau, MD, PhD, Director, Sean N. Parker Center for Allergy and Asthma Research at Stanford University, 269 Campus Drive, CCSR 3215, MC 5366, Stanford, CA 94305-5101, USA.
Email: [email protected]
Search for more papers by this authorSayantani Sindher
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorShifaa S. Alkotob
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorMelanie N. Shojinaga
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorRobert Hamilton
Divisions of Allergy and Clinical Immunology, Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Search for more papers by this authorSusan Chan
Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, St. Thomas’ Hospital, King’s College London, London, UK
Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St.Thomas’ Hospital NHS Foundation Trust, London, UK
Paediatric Allergy Group, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Guys’ Hospital, King’s College London, London, UK
Search for more papers by this authorShu Cao
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Search for more papers by this authorHenry T. Bahnson
Benaroya Research Institute and Immune Tolerance Network, Seattle, WA, USA
Search for more papers by this authorHelen A. Brough
Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, St. Thomas’ Hospital, King’s College London, London, UK
Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St.Thomas’ Hospital NHS Foundation Trust, London, UK
Paediatric Allergy Group, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Guys’ Hospital, King’s College London, London, UK
Search for more papers by this authorGideon Lack
Paediatric Allergy Group, Department of Women and Children’s Health, School of Life Course Sciences, St. Thomas’ Hospital, King’s College London, London, UK
Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St.Thomas’ Hospital NHS Foundation Trust, London, UK
Paediatric Allergy Group, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, Guys’ Hospital, King’s College London, London, UK
Search for more papers by this authorDonald Y. M. Leung
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO, USA
Search for more papers by this authorCorresponding Author
Kari C. Nadeau
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Division of Allergy, Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA
Correspondence
Kari C. Nadeau, MD, PhD, Director, Sean N. Parker Center for Allergy and Asthma Research at Stanford University, 269 Campus Drive, CCSR 3215, MC 5366, Stanford, CA 94305-5101, USA.
Email: [email protected]
Search for more papers by this author
REFERENCES
- 1Du Toit G, Roberts G, Sayre PH, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015; 372: 803-813.
- 2Perkin MR, Logan K, Tseng A, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016; 374: 1733-1743.
- 3Goleva E, Berdyshev E, Leung DY. Epithelial barrier repair and prevention of allergy. J Clin Invest. 2019; 129: 1463-1474.
- 4Lowe AJ, Leung DYM, Tang MLK, Su JC, Allen KJ. The skin as a target for prevention of the atopic march. Ann Allergy Asthma Immunol. 2018; 120: 145-151.
- 5Lowe AJ, Su JC, Allen KJ, et al. A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization: the PEBBLES pilot study. Br J Dermatol. 2018; 178: e19-e21.
- 6Simpson EL, Chalmers JR, Hanifin JM, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014; 134: 818-823.
- 7Horimukai K, Morita K, Narita M, et al. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol. 2014; 134: 824-830.e6.
- 8Elias PM, Wakefield JS, Man MQ. Moisturizers versus current and next-generation barrier repair therapy for the management of atopic dermatitis. Skin Pharmacol Physiol. 2019; 32: 1-7.
- 9Rachid R, Umetsu DT. Immunological mechanisms for desensitization and tolerance in food allergy. Semin Immunopathol. 2012; 34: 689-702.
- 10Andorf S, Bunning B, Tupa D, et al. Trends in egg specific immunoglobulin levels during natural tolerance and oral immunotherapy. Allergy. 2019. https://doi.org/10.1111/all.14107
- 11Chinthrajah RS, Purington N, Andorf S, et al. Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2019; 394: 1437-1449.
- 12Chinthrajah S, Cao S, Liu C, et al. Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy. JCI Insight. 2019; 4(22). https://doi.org/10.1172/jci.insight.131347
- 13Wisniewski J, Agrawal R, Woodfolk JA. Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. Clin Exp Allergy. 2013; 43: 164-176.
- 14Mahalingam J, Lin CY, Chiang JM, et al. CD4(+) T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer. PLoS ONE. 2014; 9:e108554.