ORIGINAL ARTICLE

Effect of Cardiac Rehabilitation in Patients with ICD: Are Gender Differences Present? Results from the COPE-ICD Trial

Corresponding Author

ANNE VINGGAARD CHRISTENSEN M.Sc.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Address for reprints: Anne Vinggaard Christensen, M.Sc., The Heart Centre, section 2151, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark. Fax: 45459526; e-mail: [email protected]Search for more papers by this author

ANN-DORTHE ZWISLER M.D., Ph.D.,

ANN-DORTHE ZWISLER M.D., Ph.D.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Department of Cardiology, Holbæk Hospital, Denmark

The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

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JESPER HASTRUP SVENDSEN M.D., D.M.S.C.,

JESPER HASTRUP SVENDSEN M.D., D.M.S.C.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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PREBEN ULRICH PEDERSEN R.N., Ph.D.,

PREBEN ULRICH PEDERSEN R.N., Ph.D.

Centre of Clinical Guidelines – Clearinghouse, Faculty of Medicine and Technology, Aalborg University, Aalborg, Denmark

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LOUISE BLUNK R.N., M.Sc.,

LOUISE BLUNK R.N., M.Sc.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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LAU CASPAR THYGESEN M.Sc., Ph.D.,

LAU CASPAR THYGESEN M.Sc., Ph.D.

The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

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SELINA KIKKENBORG BERG R.N., M.S.N., Ph.D.,

SELINA KIKKENBORG BERG R.N., M.S.N., Ph.D.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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ANNE VINGGAARD CHRISTENSEN M.Sc.,

Corresponding Author

ANNE VINGGAARD CHRISTENSEN M.Sc.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

ANN-DORTHE ZWISLER M.D., Ph.D.,

ANN-DORTHE ZWISLER M.D., Ph.D.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Department of Cardiology, Holbæk Hospital, Denmark

The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

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JESPER HASTRUP SVENDSEN M.D., D.M.S.C.,

JESPER HASTRUP SVENDSEN M.D., D.M.S.C.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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PREBEN ULRICH PEDERSEN R.N., Ph.D.,

PREBEN ULRICH PEDERSEN R.N., Ph.D.

Centre of Clinical Guidelines – Clearinghouse, Faculty of Medicine and Technology, Aalborg University, Aalborg, Denmark

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LOUISE BLUNK R.N., M.Sc.,

LOUISE BLUNK R.N., M.Sc.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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LAU CASPAR THYGESEN M.Sc., Ph.D.,

LAU CASPAR THYGESEN M.Sc., Ph.D.

The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

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SELINA KIKKENBORG BERG R.N., M.S.N., Ph.D.,

SELINA KIKKENBORG BERG R.N., M.S.N., Ph.D.

The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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First published: 16 September 2014

https://doi.org/10.1111/pace.12507

Citations: 7

Funding: This work was supported by the Novo Nordisk Foundation; the Oticon Foundation; the Danish Heart Foundation; the AP Møller and Chastine Mc-Kinney Møller Foundation; Helsefonden; the Tryg Foundation; the Krista and Viggo Petersen Foundation; the Danish Cardiovascular Research School (DaCRA); King Christian X Foundation, and Rigshospitalet, Copenhagen University Hospital.

Conflicts of Interest: None declared.

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Abstract

Background

The COPE-ICD (Copenhagen Outpatient ProgrammE-implantable cardioverter defibrillator) trial studied comprehensive cardiac rehabilitation for patients with ICDs. The purpose of this paper was to explore: (1) gender differences in self-rated health and quality of life (QoL) at hospital discharge after ICD implantation, (2) gender differences in effect of cardiac rehabilitation, and (3) predictors of effect of cardiac rehabilitation.

Methods

Patients with first-time ICD implantation were randomized to comprehensive cardiac rehabilitation versus usual care. Gender differences in self-rated health and QoL and effect of rehabilitation were tested using t-tests. Predictors of effect of rehabilitation were tested using logistic regression.

Results

A total of 196 patients (mean age 58 ± 13 years; 155 men, 41 women) were included. At hospital discharge, significant differences were found in physical component scale, mental component scale, social functioning, physical functioning, bodily pain, vitality, mental health, and QoL with men having higher scores. Among men only, significant differences were found in VO₂ (rehabilitation: 20.9 mL/min/kg [standard deviation (SD) 8.1] vs 23.4 mL/min/kg [SD 9.5] and usual care: 22.1 mL/min/kg [SD 8.1] vs 21.8 mL/min/kg [SD 8.3], P = 0.01), total exercise time (rehabilitation: 587.0 seconds [SD 249.6] vs 650.7 seconds [SD 279.8] and usual care: 613.8 seconds [SD 264.7] vs 606.1 seconds [SD 277.3], P = 0.01), and the mental component scale (rehabilitation: 47.7 points [SD 10.1] vs 54.8 points [7.1] and usual care: 48.1 points [SD 10.9] vs 51.9 points [SD 9.6], P = 0.05).

Conclusions

After ICD implantation, significant gender differences were found in physical health, mental health, and QoL. Effects of rehabilitation were found among men only and gender predicted effect of rehabilitation on the mental component scale.

References

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Volume38, Issue1

January 2015

Pages 18-27

Effect of Cardiac Rehabilitation in Patients with ICD: Are Gender Differences Present? Results from the COPE-ICD Trial

Abstract

Background

Methods

Results

Conclusions

References

Citing Literature

References

Information

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Effect of Cardiac Rehabilitation in Patients with ICD: Are Gender Differences Present? Results from the COPE-ICD Trial

Abstract

Background

Methods

Results

Conclusions

References

Citing Literature

References

Related

Information