Association between hyperglycemia and the malignant transformation of oral leukoplakia in China
Jin Li
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China
School of Stomatology, Guangdong Province, Jinan University, Guangzhou, P. R. China
Contribution: Methodology, Software, Writing - review & editing
Search for more papers by this authorYang Liu
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China
Contribution: Resources, Visualization
Search for more papers by this authorHua Zhang
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, P. R. China
Contribution: Methodology
Search for more papers by this authorCorresponding Author
Hong Hua
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China
Correspondence
Hong Hua, Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, No. 22 Zhongguancun South Avenue, Beijing 100081, P. R. China.
Email: [email protected]
Contribution: Investigation, Project administration, Validation
Search for more papers by this authorJin Li
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China
School of Stomatology, Guangdong Province, Jinan University, Guangzhou, P. R. China
Contribution: Methodology, Software, Writing - review & editing
Search for more papers by this authorYang Liu
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China
Contribution: Resources, Visualization
Search for more papers by this authorHua Zhang
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, P. R. China
Contribution: Methodology
Search for more papers by this authorCorresponding Author
Hong Hua
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, P. R. China
Correspondence
Hong Hua, Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, No. 22 Zhongguancun South Avenue, Beijing 100081, P. R. China.
Email: [email protected]
Contribution: Investigation, Project administration, Validation
Search for more papers by this authorJin Li and Yang Liu contributed equally to this work.
Abstract
Objectives
This study aimed to examine the association between hyperglycemia and the malignant transformation of oral leukoplakia (OLK).
Patients and Methods
This retrospective case–control study involved 133 patients with the malignant transformation of OLK into oral squamous cell carcinoma (case group) and 266 patients with untransformed OLK (control group). The clinical history and follow-up data included age, gender, lesion size and location, and fasting plasma glucose. Logistic regression analysis, Kaplan–Meier survival analysis, and univariate and multivariate Cox regression analyses were used to assess the effects of risk factors on the malignant transformation of OLK.
Results
Hyperglycemia (adjusted hazard ratio [AHR] = 4.7, p = .001), non-homogenous OLK (AHR = 3.0, p < .001), location of the lesion on the ventral surface of the tongue or floor of the mouth (AHR = 3.6, p < .001), and epithelial dysplasia (AHR = 2.8, p = .005) had significant effects on the malignant transformation of OLK.
Conclusion
Hyperglycemia, non-homogenous OLK, location of the lesion on the ventral surface of the tongue or floor of the mouth, and epithelial dysplasia might be associated with malignant transformation of OLK.
CONFLICTS OF INTEREST
None to declare.
Supporting Information
| Filename | Description |
|---|---|
| odi13372-sup-0001-FigS1-S5.docxWord document, 301.7 KB | Fig S1-S5 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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