Volume 13, Issue 2 pp. 137-140

CASE REPORT

An autopsy case of MM1-type sporadic Creutzfeldt–Jakob disease with long survival of 7 years

Aya Kawanami,

Aya Kawanami

orcid.org/0009-0008-7895-8995

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Akira Arakawa,

Akira Arakawa

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

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Tomoyasu Matsubara,

Tomoyasu Matsubara

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

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Masanobu Miyashita,

Masanobu Miyashita

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Yuichi Miyagi,

Yuichi Miyagi

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Kazuko Hasegawa,

Kazuko Hasegawa

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Shigeo Murayama,

Shigeo Murayama

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development and Department of Neurology, Graduate School of Medicine, Osaka University, Suita-shi, Osaka, Japan

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Saburo Yagishita,

Saburo Yagishita

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Yuko Saito,

Corresponding Author

Yuko Saito

[email protected]

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Correspondence

Yuko Saito, Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Sakae-cho, Itabashi-ku, Tokyo, Japan.

Email: [email protected]

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Aya Kawanami,

Aya Kawanami

orcid.org/0009-0008-7895-8995

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Akira Arakawa,

Akira Arakawa

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Search for more papers by this author

Tomoyasu Matsubara,

Tomoyasu Matsubara

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

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Masanobu Miyashita,

Masanobu Miyashita

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Yuichi Miyagi,

Yuichi Miyagi

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Kazuko Hasegawa,

Kazuko Hasegawa

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Shigeo Murayama,

Shigeo Murayama

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

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Saburo Yagishita,

Saburo Yagishita

Department of Neurology, National Hospital Organization, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan

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Yuko Saito,

Corresponding Author

Yuko Saito

[email protected]

Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan

Correspondence

Yuko Saito, Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Sakae-cho, Itabashi-ku, Tokyo, Japan.

Email: [email protected]

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First published: 11 September 2024

https://doi.org/10.1111/ncn3.12856

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Abstract

We report the first autopsy case of MM1-type sporadic Creutzfeldt–Jakob disease (sCJD) who survived 80 months after long-term artificial ventilatory support. The cerebral cortex and white matter exhibited severe atrophy, sparing the hippocampus. The prion protein aggregates of 10–20 μm in diameter were prominent. The structure consisted of granulofilamentous profiles. This case provides clues on how MM1-type sCJD extends pathologically after a long clinical course.

CONFLICT OF INTEREST STATEMENT

The authors declare no conflict of interests for this article.

REFERENCES

Volume13, Issue2

March 2025

Pages 137-140

An autopsy case of MM1-type sporadic Creutzfeldt–Jakob disease with long survival of 7 years

Abstract

CONFLICT OF INTEREST STATEMENT

REFERENCES

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An autopsy case of MM1-type sporadic Creutzfeldt–Jakob disease with long survival of 7 years

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