Volume 12, Issue 2 pp. 113-117

CASE REPORT

Successful treatment of seronegative immune-mediated necrotizing myopathy developing during pregnancy: A case report and literature review

Yuto Hayashi,

Yuto Hayashi

orcid.org/0009-0001-2496-0431

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Tatsuhiko Ozono,

Corresponding Author

Tatsuhiko Ozono

[email protected]

orcid.org/0000-0002-0439-6183

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

Correspondence

Tatsuhiko Ozono, Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita City, Osaka 565-0871, Japan.

Email: [email protected]

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Goichi Beck,

Goichi Beck

orcid.org/0000-0001-8890-2743

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Yuki Yonenobu,

Yuki Yonenobu

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Rika Yamashita,

Rika Yamashita

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Kensuke Ikenaka,

Kensuke Ikenaka

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Tatsusada Okuno,

Tatsusada Okuno

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Shigeo Murayama,

Shigeo Murayama

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan

Department of Neurology and Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

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Hideki Mochizuki,

Hideki Mochizuki

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Yuto Hayashi,

Yuto Hayashi

orcid.org/0009-0001-2496-0431

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Tatsuhiko Ozono,

Corresponding Author

Tatsuhiko Ozono

[email protected]

orcid.org/0000-0002-0439-6183

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

Correspondence

Tatsuhiko Ozono, Department of Neurology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita City, Osaka 565-0871, Japan.

Email: [email protected]

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Goichi Beck,

Goichi Beck

orcid.org/0000-0001-8890-2743

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Yuki Yonenobu,

Yuki Yonenobu

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Rika Yamashita,

Rika Yamashita

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Kensuke Ikenaka,

Kensuke Ikenaka

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Tatsusada Okuno,

Tatsusada Okuno

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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Shigeo Murayama,

Shigeo Murayama

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

Department of Neurology and Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

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Hideki Mochizuki,

Hideki Mochizuki

Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan

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First published: 30 October 2023

https://doi.org/10.1111/ncn3.12781

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Abstract

Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy characterized by limb weakness, markedly elevated serum creatine kinase (CK), and muscle fiber necrosis without lymphocytic infiltration. Here, we present a case of IMNM that developed during pregnancy. The patient was treated immediately with systemic corticosteroids, and muscle weakness and serum CK levels were improved without adverse effects on the pregnancy. As there are only a few reports of IMNM during pregnancy, the clinical course and treatment of IMNM during pregnancy are discussed with a review of the literature.

CONFLICT OF INTEREST STATEMENT

Authors declare no conflict of interests.

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Volume12, Issue2

March 2024

Pages 113-117

Successful treatment of seronegative immune-mediated necrotizing myopathy developing during pregnancy: A case report and literature review

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Successful treatment of seronegative immune-mediated necrotizing myopathy developing during pregnancy: A case report and literature review

Abstract

CONFLICT OF INTEREST STATEMENT

REFERENCES

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