Influence of stent implantation on erythrocyte aggregation in human native coronary arteries and saphenous vein grafts
Theodor Baars
Institute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Institute for Clinic of Cardiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorPhilipp Kahlert
Institute for Clinic of Cardiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorAlbert Baars
Department of Biomimetics, Hochschule of Bremen, City University of Applied Science, Bremen, Germany
Search for more papers by this authorHeike Preibsch
Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany
Search for more papers by this authorTienush Rassaf
Institute for Clinic of Cardiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorGerd Heusch
Institute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorCorresponding Author
Petra Kleinbongard
Institute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Correspondence
Petra Kleinbongard, Institut für Pathophysiologie, Westdeutsches Herz- und Gefäßzentrum, Universitätsklinikum Essen, Essen, Germany.
Email: [email protected]
Search for more papers by this authorTheodor Baars
Institute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Institute for Clinic of Cardiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorPhilipp Kahlert
Institute for Clinic of Cardiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorAlbert Baars
Department of Biomimetics, Hochschule of Bremen, City University of Applied Science, Bremen, Germany
Search for more papers by this authorHeike Preibsch
Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany
Search for more papers by this authorTienush Rassaf
Institute for Clinic of Cardiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorGerd Heusch
Institute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Search for more papers by this authorCorresponding Author
Petra Kleinbongard
Institute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany
Correspondence
Petra Kleinbongard, Institut für Pathophysiologie, Westdeutsches Herz- und Gefäßzentrum, Universitätsklinikum Essen, Essen, Germany.
Email: [email protected]
Search for more papers by this authorFunding Information:
This work was supported by the Dr. Heinz-Horst Deichmann Foundation.
Abstract
Objective
Stent implantation into atherosclerotic coronary vessels induces the release of particulate debris and soluble vasoactive substances, which impair downstream microvascular function. Microvascular perfusion, however, is also determined by hemorheological parameters. We therefore analyzed now changes in erythrocyte (RBC) aggregation in coronary arterial blood during stent implantation.
Methods
Symptomatic male patients with stable angina pectoris and stenosis in their native right coronary artery (RCA) or saphenous vein graft on right coronary artery (SVG-RCA) were enrolled. Coronary arterial blood was taken before and coronary aspirate during stent implantation with a distal occlusion/aspiration device. RBC aggregation was determined using the erythrocyte adhesiveness/aggregation test. The ratio of clot-free area to whole area of a spread blood drop was quantified (rCFA). To evaluate the impact of soluble factors within aspirate plasma on RBC aggregation, separated RBCs of healthy volunteers were exposed to patients' coronary arterial blood and aspirate samples.
Results
rCFA was comparably increased in coronary aspirate of RCAs and SVG-RCAs after stent implantation (RCA: 25.7±2.1% vs 32.2±2.1%; SVG-RCA: 28.9±1.9% vs 33.3±2.0%, P<.01). The rCFA of healthy volunteers was increased after adding coronary aspirate plasma.
Conclusions
Stent implantation into atherosclerotic coronary arteries induces an increase in RBC aggregation, potentially contributing to impaired microvascular perfusion.
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