HBsAg seroconversion in de novo hepatitis B virus-infected paediatric liver transplant recipients with anti-viral therapy
Chong Dong
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorZhuolun Song
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorChao Sun
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorKai Wang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorJing Chen
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorWei Zhang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorDi Wu
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorWeiping Zheng
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorYang Yang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorHong Qin
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorChao Han
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorFubo Zhang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorZhen Wang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorMin Xu
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorGuofeng Zhang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorEnbo Xie
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorJunli Jiao
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorShunqi Cao
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorCorresponding Author
Wei Gao
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Correspondence
Wei Gao, Department of Paediatric Transplantation, Organ Transplant Center, Tianjin First Central Hospital, No.24 Fukang Road, Nankai District, 300192 Tianjin, China.
Email: [email protected]
Search for more papers by this authorZhongyang Shen
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorChong Dong
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorZhuolun Song
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorChao Sun
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorKai Wang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorJing Chen
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorWei Zhang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorDi Wu
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorWeiping Zheng
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorYang Yang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorHong Qin
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorChao Han
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorFubo Zhang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorZhen Wang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorMin Xu
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorGuofeng Zhang
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorEnbo Xie
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorJunli Jiao
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorShunqi Cao
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorCorresponding Author
Wei Gao
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Correspondence
Wei Gao, Department of Paediatric Transplantation, Organ Transplant Center, Tianjin First Central Hospital, No.24 Fukang Road, Nankai District, 300192 Tianjin, China.
Email: [email protected]
Search for more papers by this authorZhongyang Shen
Department of Paediatric Transplantation, Tianjin First Central Hospital, Tianjin, China
Tianjin Key Laboratory for Organ Transplantation, Tianjin, China
Search for more papers by this authorAbstract
We investigated the clinical characteristics and therapeutic strategies for paediatric liver transplant (PLT) recipients who experienced de novo hepatitis B virus infection and the features of HBsAg seroconversion. A total of 821 PLT were performed in HBV-free recipients between January 2013 and January 2019 in Paediatric Organ Transplant Center, Tianjin First Central Hospital. Twenty-one recipients developed de novo HBV infection, the clinical data were analysed. The overall incidence of de novo HBV infection was 2.5%. Only one recipient received an HBcAb-negative graft, 20 recipients received HBcAb-positive grafts. The incidence of de novo HBV infection in HBcAb-negative and HBcAb-positive graft recipients were 0.2% and 6.3%, respectively. Fifteen de novo HBV-infected recipients showed HBsAg seroconversion, the incidence of HBsAg seroconversion was 71.4%. The median time from the diagnosis of de novo HBV infection to HBsAg seroconversion was 15 (1, 73) months. Recipients with hepatitis B surface antigen (HBsAg) titre <1000 IU/L and negative hepatitis B e antigen (HBeAg) at the time of de novo HBV infection diagnosis were more likely to achieve HBsAg seroconversion. Nucleotide analogues were effective in treating recipients with de novo HBV infection. De novo HBV infection does not impact liver graft function as well as recipient and graft survival rate. De novo HBV infection does not impact PLT recipient outcomes under close monitoring and appropriate treatment. High incidence of HBsAg seroconversion can be achieved after anti-viral therapy.
CONFLICT OF INTEREST
The authors have no potential conflict of interest to disclose.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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