Volume 65, Issue 4 pp. 223-233

ORIGINAL ARTICLE

Effect of intra-articular platelet-rich plasma or hyaluronic acid on limb function recovery in dogs with TPLO for cranial cruciate ligament rupture: a randomised controlled trial

F. Volz,

Corresponding Author

F. Volz

[email protected]

orcid.org/0009-0001-0921-1707

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Corresponding author email: [email protected]

Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Project administration (equal), Writing - original draft (equal), Writing - review & editing (equal)

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D. Eberle,

D. Eberle

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Methodology (equal), Project administration (equal), Writing - review & editing (equal)

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M. Kornmayer,

M. Kornmayer

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Writing - review & editing (equal)

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Y. Zablotski,

Y. Zablotski

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Formal analysis (equal), Validation (equal), Visualization (equal), Writing - review & editing (equal)

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A. Meyer-Lindenberg,

A. Meyer-Lindenberg

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Methodology (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal)

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F. Volz,

Corresponding Author

F. Volz

[email protected]

orcid.org/0009-0001-0921-1707

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Corresponding author email: [email protected]

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D. Eberle,

D. Eberle

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Methodology (equal), Project administration (equal), Writing - review & editing (equal)

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M. Kornmayer,

M. Kornmayer

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Writing - review & editing (equal)

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Y. Zablotski,

Y. Zablotski

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Formal analysis (equal), Validation (equal), Visualization (equal), Writing - review & editing (equal)

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A. Meyer-Lindenberg,

A. Meyer-Lindenberg

Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians-University, Munich, Germany

Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Methodology (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal)

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First published: 10 February 2024

https://doi.org/10.1111/jsap.13704

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Abstract

Objectives

This study aimed to investigate the recovery of limb function following a single intra-articular injection of platelet-rich plasma or hyaluronic acid in dogs with cranial cruciate ligament rupture treated with tibial plateau levelling osteotomy compared to dogs receiving no injection intraoperatively.

Materials and Methods

Sixty-two dogs with cranial cruciate ligament rupture, body weights of 20 to 40 kg, and no other orthopaedic conditions were enrolled in this prospective, randomised, double-blind, controlled study at the small animal clinic at LMU Munich. All dogs underwent tibial plateau levelling osteotomy. Based on random allocation, they received either a single intra-articular injection of platelet-rich plasma, hyaluronic acid or no injection intraoperatively. Gait analysis, clinical examinations, radiography of the stifle joint for osteoarthritis progression and two validated owner questionnaires were compared among groups at three timepoints postoperatively (6 weeks, 3 and 6 months). Limb function was primarily assessed by measuring the ground reaction forces.

Results

At all times postoperatively, no differences were observed among groups regarding clinical examinations, osteoarthritis score values, ground reaction forces or owner questionnaires. All dogs showed significant improvement in limb function clinically, in all ground reaction forces and in the validated questionnaires. Osteoarthritis progressed minimally during rechecks in all dogs regardless of the additional injection or not.

Clinical Significance

All dogs treated with tibial plateau levelling osteotomy for cranial cruciate ligament rupture showed improvements in limb function. No additive effect on faster recovery was demonstrated with the additional intra-articular injection of platelet-rich plasma or hyaluronic acid. Addition of platelet-rich plasma/hyaluronic acid injections during tibial plateau levelling osteotomy is unnecessary considering the lack of benefit observed up to 6 months postoperatively.

INFOGRAPHIC

Effect of intra-articular platelet-rich plasma or hyaluronic acid on limb function recovery in dogs with TPLO for cranial cruciate ligament rupture: a randomised controlled trial

Open Research

Data availability statement

The data that support the findings of this study are available from the corresponding author, [F. Volz, F.V.], upon reasonable request.

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Volume65, Issue4

April 2024

Pages 223-233

Effect of intra-articular platelet-rich plasma or hyaluronic acid on limb function recovery in dogs with TPLO for cranial cruciate ligament rupture: a randomised controlled trial

Abstract

Objectives

Materials and Methods

Results

Clinical Significance

INFOGRAPHIC

INFOGRAPHIC

Open Research

Data availability statement

References

References

Information

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Effect of intra-articular platelet-rich plasma or hyaluronic acid on limb function recovery in dogs with TPLO for cranial cruciate ligament rupture: a randomised controlled trial

Abstract

Objectives

Materials and Methods

Results

Clinical Significance

INFOGRAPHIC

INFOGRAPHIC

Open Research

Data availability statement

References

References

Related

Information