Volume 35, Issue 2 e70041
CLINICAL INVESTIGATIVE STUDY

Clinical Outcomes and Complications of Carotid Artery Stenting With or Without Pre-Stent and Post-Stent Balloon Angioplasty

Maria Martucci

Maria Martucci

Cleveland Clinic, Cleveland, Ohio, USA

Maria Martucci and Mohamad Ezzeldin are Co-First Author

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Mohamad Ezzeldin

Corresponding Author

Mohamad Ezzeldin

HCA Houston Healthcare Kingwood, Kingwood, Texas, USA

Maria Martucci and Mohamad Ezzeldin are Co-First Author

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Kaho Adachi

Kaho Adachi

University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA

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Adam Delora

Adam Delora

HCA Houston Healthcare Kingwood, Kingwood, Texas, USA

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Rime Ezzeldin

Rime Ezzeldin

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

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Ameer E. Hassan

Ameer E. Hassan

Valley Baptist Medical Center, Harlingen, Texas, USA

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Farhan Siddiq

Farhan Siddiq

University of Missouri, Columbia, Missouri, USA

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Faheem G. Sheriff

Faheem G. Sheriff

Texas Tech University Health Sciences Center, El Paso, Texas, USA

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Peter Kan

Peter Kan

University of Texas Medical Branch (UTMB), Galveston, Texas, USA

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Nazli Janjua

Nazli Janjua

Pomona Valley Hospital Medical Center, Pomona, California, USA

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Kaiz S. Asif

Kaiz S. Asif

Ascension Health, Chicago, Illinois, USA

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Ramesh Grandhi

Ramesh Grandhi

University of Utah, Salt lake city, Utah, USA

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Ali Alaraj

Ali Alaraj

University of Illinois Chicago (UIC), Chicago, Illinois, USA

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Muhammad Niazi

Muhammad Niazi

WellSpan Health, York, Pennsylvania, USA

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Ossama Mansour

Ossama Mansour

Alexandria University, Alexandria, Egypt

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Saif Bushnaq

Saif Bushnaq

Texas Tech University, Lubbock, Texas, USA

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Omar Tanweer

Omar Tanweer

Baylor St. Lukes Medical Center, Houston, Texas, USA

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Samantha Miller

Samantha Miller

Valley Baptist Medical Center, Harlingen, Texas, USA

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Navpreet K. Bains

Navpreet K. Bains

University of Missouri, Columbia, Missouri, USA

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Gabriela Colina

Gabriela Colina

Texas Tech University Health Sciences Center, El Paso, Texas, USA

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Mohammad AlMajali

Mohammad AlMajali

St. Vincent Medical Center, Toledo, Ohio, USA

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Gautam Edhayan

Gautam Edhayan

University of Texas Medical Branch (UTMB), Galveston, Texas, USA

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Musaab Froukh

Musaab Froukh

Ascension Health, Chicago, Illinois, USA

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Walid K. Salah

Walid K. Salah

University of Utah, Salt lake city, Utah, USA

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Elsa Nico

Elsa Nico

University of Illinois Chicago (UIC), Chicago, Illinois, USA

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Shehab Ashraf

Shehab Ashraf

Alexandria University, Alexandria, Egypt

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Yazan Radaideh

Yazan Radaideh

Rush University Medical Center, Chicago, Illinois, USA

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Darko Quispe-Orozco

Darko Quispe-Orozco

Texas Tech University, Lubbock, Texas, USA

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Osama Zaidat

Osama Zaidat

St. Vincent Medical Center, Toledo, Ohio, USA

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M. Shazam Hussain

M. Shazam Hussain

Cleveland Clinic, Cleveland, Ohio, USA

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First published: 22 April 2025

Funding: The authors received no specific funding for this work.

ABSTRACT

Background and Purpose

Carotid artery stenting is a well-established method for treating carotid artery stenosis; however, there are conflicting data on prestenting versus post-stenting balloon angioplasty. Our study aims to understand the risk and safety of pre-stent balloon angioplasty (Pre-SB) and post-stent balloon angioplasty (Post-SB), or both techniques.

Methods

Multicenter retrospective data on angioplasty balloons, stents, complications, and modified Rankin score (mRS) before and after the procedure were collected. Statistical analysis was performed to correlate with complication risks and clinical outcomes.

Results

1,355 patients were enrolled. Post-SB predicted fewer complications (p = 0.035) than Pre-SB or combined Pre-SB and Post-SB. Female sex was a predictor of complications (p = 0.041), while utilization of an embolic protection device predicted fewer complications (p < 0.001). Increasing age (p < 0.001) and smoking (p = 0.027) predicted increased length of stay. Using open-cell stents versus closed-cell stents did not predict follow-up modified rankin score (mRS) or complications, but using open-cell stents did predict a shorter length of stay. Conversely, open-cell stents were more likely to undergo Post-SB (p < 0.001), while closed-cell stents were more likely to undergo Pre-SB (p = 0.002).

Conclusions

Unlike previous literature, our results showed that Post-SB alone was associated with fewer complications compared to either Pre-SB alone or the combination of Pre-SB and Post-SB. Open-cell stents required a higher rate of Post-SB.

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