Original Researh

Imaging of Primary Brain Tumors and Metastases with Fast Quantitative 3-Dimensional Magnetization Transfer

Corresponding Author

Meritxell Garcia

Division of Diagnostic & Interventional Neuroradiology, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

Contributed equally to this article.

Correspondence: Address correspondence to Meritxell Garcia, University of Basel Hospital, Division of Diagnostic & Interventional Neuroradiology, Petersgraben 4, Basel, Switzerland, 4031. E-mail: [email protected].Search for more papers by this author

Monika Gloor,

Monika Gloor

Division of Radiological Physics, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

Contributed equally to this article.

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Oliver Bieri,

Oliver Bieri

Division of Radiological Physics, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

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Ernst-Wilhelm Radue,

Ernst-Wilhelm Radue

Medical Imaging Analysis Center, University of Basel Hospital, Basel, Switzerland

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Johanna M. Lieb,

Johanna M. Lieb

Division of Diagnostic & Interventional Neuroradiology, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

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Dominik Cordier,

Dominik Cordier

Department of Neurosurgery, University of Basel Hospital, Basel, Switzerland

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Christoph Stippich,

Christoph Stippich

Division of Diagnostic & Interventional Neuroradiology, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

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Meritxell Garcia,

Corresponding Author

Meritxell Garcia

Division of Diagnostic & Interventional Neuroradiology, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

Contributed equally to this article.

Monika Gloor,

Monika Gloor

Division of Radiological Physics, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

Contributed equally to this article.

Search for more papers by this author

Oliver Bieri,

Oliver Bieri

Division of Radiological Physics, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

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Ernst-Wilhelm Radue,

Ernst-Wilhelm Radue

Medical Imaging Analysis Center, University of Basel Hospital, Basel, Switzerland

Search for more papers by this author

Johanna M. Lieb,

Johanna M. Lieb

Division of Diagnostic & Interventional Neuroradiology, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

Search for more papers by this author

Dominik Cordier,

Dominik Cordier

Department of Neurosurgery, University of Basel Hospital, Basel, Switzerland

Search for more papers by this author

Christoph Stippich,

Christoph Stippich

Division of Diagnostic & Interventional Neuroradiology, Department of Radiology, Clinic for Radiology & Nuclear Medicine, University of Basel Hospital, Basel, Switzerland

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First published: 20 February 2015

https://doi.org/10.1111/jon.12222

Citations: 20

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ABSTRACT

BACKGROUND AND PURPOSE

This study assesses whether magnetization transfer (MT) imaging provides additive information to conventional MRI in brain tumors.

METHODS

MT data of 26 patients with neoplastic and metastatic brain tumors were analyzed at 1.5 T. For the 3 largest tumor groups investigated in this study—glioblastoma multiforme (GBM), meningiomas, and metastases—statistical comparisons were performed. Analyzed MT parameters included the magnetization transfer ratio (MTR) and 4 quantitative MT parameters (qMT): Relaxation times (T1, T2), exchange rate (kf), and macromolecular content (F). Total imaging time of high-resolution whole brain MTR and qMT imaging with balanced steady-state free precession required 9 minutes. Five ROIs were chosen: Contrast-enhancing (T1W-CE), noncontrast-enhancing (T1W-non-CE), proximal hyperintensity (T2W-pSI), distal hyperintensity (T2W-dSI), and a reference (ref).

RESULTS

Pathologies showed significant (P < .05) MT changes (MTR and qMT) compared to the reference. The T1W-CE, T1W-non-CE, and T2W-pSI ROIs of GBMs, meningiomas, and metastases showed significant differences in MTR and qMT estimates. Similar MTR with significant different qMT values were observed in several ROIs among different lesions. MT maps (MTR and qMT) indicated changes in tissue appearing unaffected on MRI in most glial tumors.

CONCLUSIONS

MTR and qMT imaging enables a better differentiation between brain tumors and provides additive information to MRI.

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Volume25, Issue6

November/December 2015

Pages 1007-1014

Imaging of Primary Brain Tumors and Metastases with Fast Quantitative 3-Dimensional Magnetization Transfer

ABSTRACT

BACKGROUND AND PURPOSE

METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

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Imaging of Primary Brain Tumors and Metastases with Fast Quantitative 3-Dimensional Magnetization Transfer

ABSTRACT

BACKGROUND AND PURPOSE

METHODS

RESULTS

CONCLUSIONS

References

Citing Literature

References

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