Heart transplantation from donation after circulatory death donors: Present and future
Corresponding Author
Mohammed Quader MD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Correspondence Mohammed Quader, MD, Assoc Prof, Virginia Commonwealth University, Cardio-Thoracic Surgery, 1200 East Broad St, West Hospital, 7th Floor, Richmond, VA 23298.
Email: [email protected]
Search for more papers by this authorStefano Toldo PhD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorQun Chen MD, PhD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorGreg Hundley MD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorVigneshwar Kasirajan MD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorCorresponding Author
Mohammed Quader MD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Correspondence Mohammed Quader, MD, Assoc Prof, Virginia Commonwealth University, Cardio-Thoracic Surgery, 1200 East Broad St, West Hospital, 7th Floor, Richmond, VA 23298.
Email: [email protected]
Search for more papers by this authorStefano Toldo PhD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorQun Chen MD, PhD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorGreg Hundley MD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorVigneshwar Kasirajan MD
Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
Search for more papers by this authorAbstract
The first successful human heart transplantation was reported on 3 December 1967, by Christiaan Barnard in South Africa. Since then this life-saving procedure has been performed in over 120 000 patients. A limitation to the performance of this procedure is the availability of donor hearts with as many as 20% of patients dying before a donor's heart is available for transplant. Today, hearts for transplantation are procured from individuals experiencing donation after brain death (DBD). Interestingly, this, however, was not always the case as the first heart transplants occurred after circulatory death. Revisiting the availability of hearts for transplant from those experiencing donation after circulatory death (DCD) could further expand the number of hearts suitable for transplantation. There are several considerations pertinent to transplanting hearts from those undergoing circulatory death. In this review, we summarize the main distinctions between DBD and DCD heart donation and discuss the research relevant to increasing the number of hearts available for transplantation by including individual's hearts that experience circulatory death.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
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