Volume 25, Issue 4 pp. 350-355
RESEARCH REPORT

Incidence and mortality rates of Guillain-Barré syndrome in Serbia

Aleksandar Stojanov

Aleksandar Stojanov

Neurology Clinic, Clinical Center Nis, Nis, Serbia

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Ivana Berisavac

Ivana Berisavac

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Ivo Bozovic

Ivo Bozovic

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

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Mirjana Arsenijevic

Mirjana Arsenijevic

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

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Sonja Lukic-Rajic

Sonja Lukic-Rajic

Neurology Clinic, Clinical Center of Vojvodina, Novi Sad, Serbia

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Milutin Petrovic

Milutin Petrovic

Neurology Clinic, Clinical Center Kragujevac, Kragujevac, Serbia

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Olivera Stojiljkovic-Tamas

Olivera Stojiljkovic-Tamas

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

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Zita Jovin

Zita Jovin

Neurology Clinic, Clinical Center of Vojvodina, Novi Sad, Serbia

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Gordana Djordjevic

Gordana Djordjevic

Neurology Clinic, Clinical Center Nis, Nis, Serbia

Faculty of Medicine, University of Nis, Nis, Serbia

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Dejana Jovanovic

Dejana Jovanovic

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Miroslav Stojanovic

Miroslav Stojanovic

Neurology Clinic, Clinical Center Kragujevac, Kragujevac, Serbia

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Vesna Martic

Vesna Martic

Neurology Clinic, Military Medical Academy, Belgrade, Serbia

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Ivana Basta

Ivana Basta

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Stojan Peric

Corresponding Author

Stojan Peric

Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia

Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Correspondence

Stojan Peric, MD, PhD, Dr Subotic Street 6, 11000 Belgrade, Serbia.

Email: [email protected]

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First published: 31 August 2020
Citations: 14

Abstract

Guillain-Barré syndrome (GBS) is an acute auto-immune polyradiculoneuropathy. A huge variety of GBS incidence and mortality rates has been noted across the world. The objective of the present multi-centric study was to assess the incidence and mortality rates of GBS during a 10-year period in Serbia. We collected data of adult GBS patients who were hospitalized from 2009 to 2018 in all five tertiary healthcare centers in Serbia. The incidence rates per 100 000 inhabitants with 95% confidence intervals (CI) were calculated and further corrected for the estimated number of patients hospitalized in secondary centers. Mortality rates were also assessed. GBS was considered severe if patients were not able to walk at least 10 m without assistance. Six hundred and forty GBS patients were registered in tertiary centers in a 10-year period. The proportion of severe cases was 75% at nadir, and 52% on discharge. GBS incidence rate in Serbia was 1.1 per 100 000 inhabitants, and estimated incidence if patients from secondary centers included 1.2 per 100 000. Peak incidence was observed during the sixth decade of life. During the acute phase, 5.6% of GBS patients died, while overall 9.7% of them died during 6-month period from disease onset. This study contributes to our knowledge about GBS epidemiology. Results will allow us to improve the diagnosis and treatment of GBS patients in Serbia.

CONFLICT OF INTEREST

The authors declare no conflicts of interest.

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