CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection
Corresponding Author
Denise C. Hsu
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
Correspondence
Denise Hsu, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
Email: [email protected]
Search for more papers by this authorMatthew D. Wegner
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorPiyanate Sunyakumthorn
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorDecha Silsorn
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorSujitra Tayamun
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorDutsadee Inthawong
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorYanin Kuncharin
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorRawiwan Im-Erbsin
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorChristine Ege
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorRobert J. O'Connell
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Search for more papers by this authorNelson L. Michael
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Search for more papers by this authorLishomwa C. Ndhlovu
John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
Search for more papers by this authorSandhya Vasan
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
Search for more papers by this authorCorresponding Author
Denise C. Hsu
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
Correspondence
Denise Hsu, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
Email: [email protected]
Search for more papers by this authorMatthew D. Wegner
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorPiyanate Sunyakumthorn
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorDecha Silsorn
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorSujitra Tayamun
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorDutsadee Inthawong
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorYanin Kuncharin
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorRawiwan Im-Erbsin
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorChristine Ege
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Search for more papers by this authorRobert J. O'Connell
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Search for more papers by this authorNelson L. Michael
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Search for more papers by this authorLishomwa C. Ndhlovu
John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
Search for more papers by this authorSandhya Vasan
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
Search for more papers by this authorFunding information
This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. and the U.S. Department of the Army
Abstract
Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.
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