Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata)
Corresponding Author
Takako Miyabe-Nishiwaki
Primate Research Institute, Kyoto University, Aichi, Japan
T. Miyabe-Nishiwaki and A. Hirata are contribute equally to the work.Correspondence
Takako Miyabe-Nishiwaki, Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Aichi, Japan.
Email: [email protected]
Search for more papers by this authorAkihiro Hirata
Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu, Japan
T. Miyabe-Nishiwaki and A. Hirata are contribute equally to the work.Search for more papers by this authorAkihisa Kaneko
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorAkiyo Ishigami
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorYoko Miyamoto
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorAtsushi Yamanaka
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorKeishi Owaki
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Search for more papers by this authorHiroki Sakai
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Search for more papers by this authorTokuma Yanai
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Search for more papers by this authorJuri Suzuki
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorCorresponding Author
Takako Miyabe-Nishiwaki
Primate Research Institute, Kyoto University, Aichi, Japan
T. Miyabe-Nishiwaki and A. Hirata are contribute equally to the work.Correspondence
Takako Miyabe-Nishiwaki, Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Aichi, Japan.
Email: [email protected]
Search for more papers by this authorAkihiro Hirata
Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu, Japan
T. Miyabe-Nishiwaki and A. Hirata are contribute equally to the work.Search for more papers by this authorAkihisa Kaneko
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorAkiyo Ishigami
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorYoko Miyamoto
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorAtsushi Yamanaka
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorKeishi Owaki
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Search for more papers by this authorHiroki Sakai
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Search for more papers by this authorTokuma Yanai
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
Search for more papers by this authorJuri Suzuki
Primate Research Institute, Kyoto University, Aichi, Japan
Search for more papers by this authorAbstract
Background
A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.
Methods
The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.
Results
The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and hepatocyte paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.
Conclusion
To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.
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