Functional dyspepsia symptom diary is correlated with other questionnaires and associated with severity in patients with functional dyspepsia: a multicenter, prospective observational study
Xin Shi
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Xin Shi, Hui Luo, and Xiangping Wang contributed equally to the work.Search for more papers by this authorHui Luo
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Xin Shi, Hui Luo, and Xiangping Wang contributed equally to the work.Search for more papers by this authorXiangping Wang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Xin Shi, Hui Luo, and Xiangping Wang contributed equally to the work.Search for more papers by this authorGui Ren
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorLinhui Zhang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorQin Tao
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorShuhui Liang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorNa Liu
Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorXiaojun Huang
Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, China
Search for more papers by this authorXiaoyin Zhang
Department of Gastroenterology, National Clinical Research Center of Infectious Disease, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China
Search for more papers by this authorHui Deng
Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Intelligent Non-Invasive Neuromodulation and Transformation Joint Laboratory, School of Life Science and Technology, Xidian University, Xi'an, China
Search for more papers by this authorWei Qin
Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Intelligent Non-Invasive Neuromodulation and Transformation Joint Laboratory, School of Life Science and Technology, Xidian University, Xi'an, China
Search for more papers by this authorXiaoyu Kang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorCorresponding Author
Yanglin Pan
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Correspondence
Dr Yanglin Pan and Dr Daiming Fan, State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.
Email: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Daiming Fan
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Correspondence
Dr Yanglin Pan and Dr Daiming Fan, State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.
Email: [email protected]; [email protected]
Search for more papers by this authorXin Shi
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Xin Shi, Hui Luo, and Xiangping Wang contributed equally to the work.Search for more papers by this authorHui Luo
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Xin Shi, Hui Luo, and Xiangping Wang contributed equally to the work.Search for more papers by this authorXiangping Wang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Xin Shi, Hui Luo, and Xiangping Wang contributed equally to the work.Search for more papers by this authorGui Ren
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorLinhui Zhang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorQin Tao
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorShuhui Liang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorNa Liu
Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
Search for more papers by this authorXiaojun Huang
Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, China
Search for more papers by this authorXiaoyin Zhang
Department of Gastroenterology, National Clinical Research Center of Infectious Disease, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China
Search for more papers by this authorHui Deng
Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Intelligent Non-Invasive Neuromodulation and Transformation Joint Laboratory, School of Life Science and Technology, Xidian University, Xi'an, China
Search for more papers by this authorWei Qin
Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Intelligent Non-Invasive Neuromodulation and Transformation Joint Laboratory, School of Life Science and Technology, Xidian University, Xi'an, China
Search for more papers by this authorXiaoyu Kang
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Search for more papers by this authorCorresponding Author
Yanglin Pan
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Correspondence
Dr Yanglin Pan and Dr Daiming Fan, State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.
Email: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Daiming Fan
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China
Correspondence
Dr Yanglin Pan and Dr Daiming Fan, State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China.
Email: [email protected]; [email protected]
Search for more papers by this authorDeclaration of conflict of interest: The authors declare that they have no conflict of interest. The authors alone are responsible for the content and writing of the paper.
Author contributions: Yanglin Pan performed the study concept and design; Hui Luo, Xiangping Wang, Gui Ren, Linhui Zhang, Qin Tao, Shuhui Liang, Na Liu, Xiaojun Huang, and Xiaoying Zhang carried out the acquisition of data; Hui Deng and Wei Qin analyzed and interpreted the data; Xin Shi and Yanglin Pan made the drafting and editing of the manuscript; Daiming Fan was responsible for the critical revision of the manuscript for important intellectual content; Xin Shi and Hui Luo performed the statistical analysis. All authors approved the final version of the article, including the authorship list.
Financial support: This work was supported in part by the National Natural Science Foundation of China (81970557).
Guarantor of the article: Daiming Fan.
Abstract
Background and Aim
Functional dyspepsia symptom diary (FDSD) is a newly designed questionnaire of functional dyspepsia (FD). The relationships between FDSD and other FD-related questionnaires and patient-reported severity remain unclear. This study aims to investigate the correlations between FDSD and other questionnaires and to determine the relationships between FDSD and FD severity.
Methods
Consecutive outpatients with FD were prospectively enrolled in four tertiary hospitals. All patients were evaluated by six FD-related questionnaires, including FDSD, Dyspepsia Symptom Severity Index (DSSI), Gastrointestinal Symptom Rating Scale, Short-Form Nepean Dyspepsia Index, and Hamilton Depression and Anxiety Scale (HAMD and HAMA). The severity of FD was also graded as mild, moderate, and severe by patients themselves. Correlations between different scores were assessed by Spearman correlation coefficient (ρ), and risk factors for patient-reported severity were identified.
Results
For 512 enrolled FD patients, the overall median FDSD score was 19 (2–42). FDSD was well correlated with DSSI (ρ = 0.64) and fairly correlated with the other four scores (ρ = 0.32–0.55) (all P < 0.001). Mild, moderate, and severe FD were reported by 18.5%, 55.9%, and 25.6% of patients, respectively. There were seven factors associated with the severe FD, including education level, duration, and subtypes of FD, prior treatment, FDSD, HAMD, and HAMA scores (all P < 0.10). FDSD ≥ 20 (odds ratio [OR] 3.3, 95% confidence interval [CI]: 2.0–5.2, P < 0.001) and HAMD ≥ 13 (OR 2.9, 95% CI: 1.8–4.6, P < 0.001) were independently associated with patient-reported severe FD.
Conclusions
This study firstly revealed that the newly developed FDSD correlated with other FD-related questionnaires. FDSD ≥ 20 and HAMD ≥ 13 were independently associated with severe FD reported by patients (clinicaltrials.gov number: NCT04953975).
Supporting Information
| Filename | Description |
|---|---|
| jgh15854-sup-0001-supplementary figure.tiffTIFF image, 188.1 KB |
Figure S1.Receiver operating curves of FDSD for discriminating mild from moderate/severe functional dyspepsia. |
| jgh15854-sup-0002-Supplementary tables.docxWord 2007 document , 21.6 KB |
Table S1.Disease definition and corresponding examinations. Table S2. Multiple linear regression model with FDSD as the dependent variable. Table S3. Baseline characteristics and FD related questionnaire scores of patients with present Hp infection and patients prior received Hp eradication. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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