Positive correlation between pancreatic volume and post-endoscopic retrograde cholangiopancreatography pancreatitis
Corresponding Author
Hirotsugu Maruyama
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Correspondence
Hirotsugu Maruyama, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Email: [email protected]
Search for more papers by this authorMasatsugu Shiba
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorYuki Ishikawa-Kakiya
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorKunihiro Kato
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorMasaki Ominami
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorShusei Fukunaga
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorKoji Otani
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorShuhei Hosomi
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorFumio Tanaka
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorNoriko Kamata
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorKoichi Taira
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorYasuaki Nagami
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorHirokazu Yamagami
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorTetsuya Tanigawa
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorToshio Watanabe
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorAkira Yamamoto
Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorDaijiro Kabata
Department of Medical Statistics, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorAyumi Shintani
Department of Medical Statistics, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorYasuhiro Fujiwara
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorCorresponding Author
Hirotsugu Maruyama
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Correspondence
Hirotsugu Maruyama, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Email: [email protected]
Search for more papers by this authorMasatsugu Shiba
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorYuki Ishikawa-Kakiya
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorKunihiro Kato
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorMasaki Ominami
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorShusei Fukunaga
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorKoji Otani
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorShuhei Hosomi
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorFumio Tanaka
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorNoriko Kamata
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorKoichi Taira
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorYasuaki Nagami
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorHirokazu Yamagami
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorTetsuya Tanigawa
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorToshio Watanabe
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorAkira Yamamoto
Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorDaijiro Kabata
Department of Medical Statistics, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorAyumi Shintani
Department of Medical Statistics, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorYasuhiro Fujiwara
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
Search for more papers by this authorAbstract
Background and Aim
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains the most common and serious adverse event associated with ERCP. Risk factors for PEP have been described in various reports. However, risk factors have not been quantified to date. The aim of this study was to investigate the risk factors for PEP by quantification of pancreatic volume using pre-ERCP images.
Methods
Overall, 800 patients were recruited from April 2012 to February 2015 for this study. There were 168 patients who satisfied the inclusion criteria. Measurement of pancreatic volume was achieved using the volume analyzer SYNAPSE VINCENT in all cases and was used to evaluate the risk factors for PEP.
Results
According to the criteria established by the consensus guidelines (Cotton classification), 17 patients (10.1%) were classified as having mild disease, 4 (2.4%) as having moderate disease, and 5 (3.0%) as having severe disease. Multivariate model analysis showed that a large pancreatic volume was a significant risk factor for PEP (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.06–1.13; P < 0.001). In addition, the association between the pancreatic volume and the severity of PEP was positively correlated (the effect of volume [per 1 mL]; OR 1.09, 95% CI 1.07–1.12; P < 0.001, the effect of volume [per 10 mL]; OR 2.27, 95% CI 1.72–3.00; P < 0.001). A larger pancreatic volume was significantly associated with a higher incidence of PEP.
Conclusions
A large pancreatic volume was identified as a risk factor for PEP. The results of this study suggest that pre-ERCP images might be useful for predicting PEP.
Supporting Information
| Filename | Description |
|---|---|
| JGH_14878_supp0001_figure1.tifTIFF image, 106.3 KB |
Figure S1. The association between the pancreatic volume and amount of change in serum level of amylase (before and 24 hours after the endoscopic procedure). The multivariable linear regression analysis showed that as the pancreatic volume increased, the amount of change in serum level of amylase increased (before and 24 hours after the endoscopic procedure). The Figure showed that the amount of change in serum level of amylase will be 152.3 U/L if volume changes by 10ml. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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