Association of salivary peroxidase activity and concentration with periodontal health: A validity study
Corresponding Author
Maral Memarzadeh Zahedani
Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School of University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Correspondence
Maral Memarzadeh Zahedani, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental school of University Medicine Greifswald, Greifswald, Germany.
Email: [email protected]
Search for more papers by this authorChristian Schwahn
Department of Prosthetic Dentistry, Gerodontology and Biomaterials, Dental School of University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Search for more papers by this authorRomy Baguhl
Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorThomas Kocher
Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School of University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorHarald Below
Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Search for more papers by this authorAlexander Welk
Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School of University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Search for more papers by this authorCorresponding Author
Maral Memarzadeh Zahedani
Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School of University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Correspondence
Maral Memarzadeh Zahedani, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental school of University Medicine Greifswald, Greifswald, Germany.
Email: [email protected]
Search for more papers by this authorChristian Schwahn
Department of Prosthetic Dentistry, Gerodontology and Biomaterials, Dental School of University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Search for more papers by this authorRomy Baguhl
Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorThomas Kocher
Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School of University Medicine Greifswald, Greifswald, Germany
Search for more papers by this authorHarald Below
Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Search for more papers by this authorAlexander Welk
Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School of University Medicine Greifswald, Greifswald, Germany
Contributed equally to this work.Search for more papers by this authorFunding information
The study was supported by European regional development Fund: V-630-S-137-2012/024, V-630-F-137-2012/023, V-630-VB243-2012/022 and by bmp bulk medicines & pharmaceuticals production gmbh and by University Medicine Greifswald.
The Study of Health in Pomerania (SHIP) is part of the Research Network Community Medicine of the University Medicine Greifswald, which is funded by the German Federal State of Mecklenburg-Vorpommern.
Abstract
Aim
Whereas the relationship between myeloperoxidase and periodontitis has been widely examined that between salivary peroxidase and periodontitis has received little attention. We examined how periodontitis depends on both salivary peroxidase activity and concentration.
Materials and Methods
A full mouth, clinical assessment of probing depth was performed in a sample of 46 participants aged 25–54 years. To minimise bias, these data were corrected by data from the general population (Study of Health in Pomerania). Using five repeated measurements of activity and concentration over 1 day, we assessed daily biological variability and increased the reliability of salivary peroxidase measurements.
Results
Salivary peroxidase activity was associated with probing depth (interquartile range effect = −0.48; robust estimates of 95% confidence interval: −0.90 to −0.31; p = .0052), and its effect was not confounded by salivary peroxidase concentration. In turn, the effect of salivary peroxidase concentration was confounded by salivary peroxidase activity, and it was smaller than that of activity.
Conclusions
We found an inverse association between salivary peroxidase activity and probing depth. Thus, our results imply that salivary peroxidase activity could be a protective factor against periodontitis. However, large, well-designed studies are needed to explore the causal mechanisms of this association.
Supporting Information
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