Assessment of arterial stiffness in periodontitis using a novel pulse wave imaging methodology
Corresponding Author
Elena C. Sanz-Miralles
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
Correspondence
Elena C. Sanz-Miralles, Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA.
Email: [email protected]
Search for more papers by this authorRonny Li
Department of Biomedical Engineering, Columbia University, New York, NY, USA
Search for more papers by this authorFatemeh Momen-Heravi
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
Search for more papers by this authorCarlos Mendieta
Periodontics Unit, Faculty of Odontology, University of Barcelona, Barcelona, Spain
Search for more papers by this authorElisa E. Konofagou
Department of Biomedical Engineering, Columbia University, New York, NY, USA
Search for more papers by this authorPanos N. Papapanou
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
Search for more papers by this authorCorresponding Author
Elena C. Sanz-Miralles
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
Correspondence
Elena C. Sanz-Miralles, Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA.
Email: [email protected]
Search for more papers by this authorRonny Li
Department of Biomedical Engineering, Columbia University, New York, NY, USA
Search for more papers by this authorFatemeh Momen-Heravi
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
Search for more papers by this authorCarlos Mendieta
Periodontics Unit, Faculty of Odontology, University of Barcelona, Barcelona, Spain
Search for more papers by this authorElisa E. Konofagou
Department of Biomedical Engineering, Columbia University, New York, NY, USA
Search for more papers by this authorPanos N. Papapanou
Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, College of Dental Medicine, Columbia University, New York, NY, USA
Search for more papers by this authorFunding information
The study was supported by the Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, and the Ultrasound Elasticity Imaging Laboratory, Columbia University Medical Center, New York, NY.
Abstract
Aim
We investigated the cross-sectional relationship between periodontal status and arterial stiffness, assessed through a novel Pulse Wave Imaging methodology.
Methods
Eighty volunteers were enrolled (39% male, age range 24–78 years) and 33 pairs were formed of periodontitis patients/periodontally healthy controls, matched by age and gender. A full-mouth periodontal examination was performed and the degree of stiffness of the right and left carotid arteries was assessed by measuring pulse wave velocity (PWV) and the uniformity in pulse wave propagation (R2). Wilcoxon signed-rank tests for paired observations were used to compare periodontitis patients and healthy controls. Univariate and multivariate analyses were performed to analyze the association between PWV and R2 and potential explanatory variables.
Results
Patients with periodontitis had a statistically significantly lower uniformity in wave propagation (R2) than controls (p = .01), but PWV did not differ between the two groups. Univariate analysis showed a significant negative association between R2 and periodontitis, body mass index and smoking; periodontitis remained statistically associated with R2 in the multivariate analyses.
Conclusions
Patients with periodontitis and no established cardiovascular disease presented with lower degree of uniformity in the transmission of the pulse wave through the carotid arteries, suggesting an association between periodontitis and arterial stiffness/functional alterations.
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