Effects of diarylpentanoid analogues of curcumin on chemiluminescence and chemotactic activities of phagocytes
Corresponding Author
Ibrahim Jantan
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Ibrahim Jantan, Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. E-mail: [email protected]Search for more papers by this authorSyed Nasir Abbas Bukhari
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Search for more papers by this authorNordin Haji Lajis
Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Search for more papers by this authorFaridah Abas
Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Search for more papers by this authorLam Kok Wai
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Search for more papers by this authorMalina Jasamai
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Search for more papers by this authorCorresponding Author
Ibrahim Jantan
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Ibrahim Jantan, Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. E-mail: [email protected]Search for more papers by this authorSyed Nasir Abbas Bukhari
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Search for more papers by this authorNordin Haji Lajis
Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Search for more papers by this authorFaridah Abas
Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Search for more papers by this authorLam Kok Wai
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Search for more papers by this authorMalina Jasamai
Drug and Herbal Research Center, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur
Search for more papers by this authorAbstract
Objectives A series of 43 curcumin diarylpentanoid analogues were synthesized and evaluated for their inhibitory effects on the chemiluminescence and chemotactic activity of phagocytes in vitro.
Methods The effects of the compounds on the respiratory burst of human whole blood and isolated human polymorphonuclear leukocytes (PMNs) were evaluated using a luminol-based chemiluminescence assay and their effect on chemotactic migration of PMNs was investigated using the Boyden chamber technique.
Key findings Compounds 6, 17, 25 and 30 exhibited significant inhibitory activity on the oxidative burst of PMNs. The presence of methoxy groups at positions 2 and 5, and methoxylation and fluorination at positions 4 and 2 of both phenyl rings, respectively, may contribute significantly to their reactive oxygen species inhibition activity. Compounds 7, 17, 18, 24 and 32 showed strong inhibition of the chemotaxis migration of PMNs. Chlorination at various positions of both phenyl rings of cyclohexanone diarylpentanoid resulted in compounds with potent inhibitory effects on PMN migration.
Conclusions The results suggest that some of these diarylpentanoid analogues are able to modulate the innate immune response of phagocytes at different steps, emphasizing their potential as a source of new immunomodulatory agents.
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