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α₂-Adrenoceptor Changes During Cerebral Ageing. The Effect of Ginkgo biloba Extract

Corresponding Author

FRANÇOIS HUGUET

INSERM U. 316, Tours, and Laboratoire de Toxicologie, Facullé de Médecine el de Pharmacie, Poitiers, France

Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie, 34 rue du jardin des Plantes, 86034 Poitiers cedex, France.Search for more papers by this author

THIERRY TARRADE,

THIERRY TARRADE

Institut Henri Beaufour, Paris, France

Search for more papers by this author

FRANÇOIS HUGUET,

Corresponding Author

FRANÇOIS HUGUET

INSERM U. 316, Tours, and Laboratoire de Toxicologie, Facullé de Médecine el de Pharmacie, Poitiers, France

Laboratoire de Toxicologie, Faculté de Médecine et de Pharmacie, 34 rue du jardin des Plantes, 86034 Poitiers cedex, France.Search for more papers by this author

THIERRY TARRADE,

THIERRY TARRADE

Institut Henri Beaufour, Paris, France

Search for more papers by this author

First published: January 1992

https://doi.org/10.1111/j.2042-7158.1992.tb14357.x

Citations: 41

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Abstract

Abstract— [³H]Rauwolscine binding to α₂-adrenoceptors in cerebral cortex and hippocampus membranes of young (4 months) and aged (24 months) Wistar rats has been investigated. In aged rats, B_max values of [³H]rauwolscine binding were significantly reduced (25–32%) in the cerebral cortex and hippocampus, as compared with the number of α₂-adrenoceptors found in young rats. Chronic treatment with Ginkgo biloba extract did not alter [³H]rauwolscine binding in the hippocampus of young rats, but significantly increased (28%) the [³H]rauwolscine binding density in aged rats. These data confirm the previously described age-related noradrenergic alteration and suggest that noradrenergic activity in aged rats is more susceptible to Ginkgo biloba extract treatment.

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Volume44, Issue1

January 1992

Pages 24-27

α₂-Adrenoceptor Changes During Cerebral Ageing. The Effect of Ginkgo biloba Extract

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α₂-Adrenoceptor Changes During Cerebral Ageing. The Effect of Ginkgo biloba Extract