Opioid Properties of Some Isomeric Derivatives of Phencyclidine
Corresponding Author
A. F. CASY
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y, UK
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.Search for more papers by this authorG. H. DEWAR
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y, UK
Search for more papers by this authorO. A. A. AL-DEEB
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y, UK
Faculty of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudia Arabia.
Search for more papers by this authorCorresponding Author
A. F. CASY
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y, UK
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.Search for more papers by this authorG. H. DEWAR
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y, UK
Search for more papers by this authorO. A. A. AL-DEEB
School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7A Y, UK
Faculty of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudia Arabia.
Search for more papers by this authorAbstract
Abstract— The phencyclidine analogues (±)-α-, (±)-β-, and (+)-α- and (–)-α-4-hydroxy-3-methyl-4-phenyl-l-(1-phenylcyclohexyl)piperidine, all with known relative and absolute stereochemistry, have been prepared, and their analgesic potencies related to corresponding prodines. In contrast to the prodines, the (±)-α-phencyclidine analogue was a more potent analgesic than its diastereoisomer, while in agreement with observations in the prodine series, the 3R, 4S-α-enantiomer displayed substantially greater potency than its mirror image form.
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