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The Pathological Diagnosis of Specific Inflammatory Myopathies
Stirling Carpenter,
George Karpati,
Corresponding Author
Stirling Carpenter
Department of Neurology, Neurosurgery, McGill University, and Montreal Neurological Institute, Montreal, Quebec, H3A 2B4 Canada
Corresponding author: Dr. S. Carpenter, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada Tel. +1 (514) 398 1914; Fax +1 (514) 398 8540Search for more papers by this authorGeorge Karpati
Department of Neurology, Neurosurgery, McGill University, and Montreal Neurological Institute, Montreal, Quebec, H3A 2B4 Canada
Search for more papers by this authorStirling Carpenter,
George Karpati,
Corresponding Author
Stirling Carpenter
Department of Neurology, Neurosurgery, McGill University, and Montreal Neurological Institute, Montreal, Quebec, H3A 2B4 Canada
Corresponding author: Dr. S. Carpenter, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada Tel. +1 (514) 398 1914; Fax +1 (514) 398 8540Search for more papers by this authorGeorge Karpati
Department of Neurology, Neurosurgery, McGill University, and Montreal Neurological Institute, Montreal, Quebec, H3A 2B4 Canada
Search for more papers by this authorAbstract
Pathological diagnosis of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM) should be possible in almost all cases when an appropriately involved muscle is biopsied. DM shows characteristic patterns of muscle fiber damage and capillary damage. Lymphocytes and macrophages are seen in PM and IBM partially invading non-necrotic fibers. IBM is also characterized by rimmed vacuoles with membranous whorls, characteristic masses of filaments in cytoplasm and sometimes in nuclei, and grouped atrophic fibers. Muscle fiber damage in PM is more variable. Inflammatory myopathy can be associated with HTLV-1 and HIV infection. In the latter a strong resemblance to PM is reported. Separate, still less well characterized forms of inflammatory myopathy occur in young children.
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