Controversies in Pregnancy and Congenital Heart Disease
Corresponding Author
Lorna Swan MD
Department of Cardiology, Western Infirmary, Glasgow, UK;
The Adult Congenital Heart Programme, Royal Brompton Hospital/National Heart & Lung Institute, Imperial College, London, UK
Lorna Swan, MD, Adult Congenital Heart Programme, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. Tel: (+44) 20-7351-8227; Fax: (+44) 20-7351-8629; E-mail: [email protected]Search for more papers by this authorMartin Lupton MD
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
Search for more papers by this authorJohn Anthony MD
Department of Obstetrics & Gynecology, University of Cape Town, South Africa;
Search for more papers by this authorSteve M. Yentis MBBS
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
Magill Department of Anesthesia, Intensive Care & Pain Management, Chelsea & Westminster Hospital, London, UK;
Search for more papers by this authorPhilip J. Steer MD
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
Search for more papers by this authorMichael A. Gatzoulis MD
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
The Adult Congenital Heart Programme, Royal Brompton Hospital/National Heart & Lung Institute, Imperial College, London, UK
Search for more papers by this authorCorresponding Author
Lorna Swan MD
Department of Cardiology, Western Infirmary, Glasgow, UK;
The Adult Congenital Heart Programme, Royal Brompton Hospital/National Heart & Lung Institute, Imperial College, London, UK
Lorna Swan, MD, Adult Congenital Heart Programme, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. Tel: (+44) 20-7351-8227; Fax: (+44) 20-7351-8629; E-mail: [email protected]Search for more papers by this authorMartin Lupton MD
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
Search for more papers by this authorJohn Anthony MD
Department of Obstetrics & Gynecology, University of Cape Town, South Africa;
Search for more papers by this authorSteve M. Yentis MBBS
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
Magill Department of Anesthesia, Intensive Care & Pain Management, Chelsea & Westminster Hospital, London, UK;
Search for more papers by this authorPhilip J. Steer MD
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
Search for more papers by this authorMichael A. Gatzoulis MD
High-Risk Obstetrics Unit, Chelsea & Westminster Hospital and Imperial College, London, UK;
The Adult Congenital Heart Programme, Royal Brompton Hospital/National Heart & Lung Institute, Imperial College, London, UK
Search for more papers by this authorABSTRACT
As increasing numbers of children with congenital heart disorders reach adulthood, the family physician, cardiologist, and obstetrician will increasingly be called upon to give advice regarding the safety of pregnancy. This need has been further highlighted by the recognition that maternal mortality associated with cardiac disease is rising. Unfortunately, this field of practice remains relatively “evidence-sparse” with many management decisions being guided by anecdote and “best guess” common sense. Not surprisingly, this results in many fundamental controversies over the optimal care these patients should receive. This article highlights, through the use of case histories, some of these contentious areas, reflecting the different manifestations of congenital maternal cardiac disease and highlighting the limitations of our knowledge.
References
- 1 Why Mothers Die 2000–2002. The Confidential Enquiries Into Maternal Deaths in the United Kingdom. London: RCOG Press; 2004. Available at: http://www.cemach.org.uk/publications/WMD2000-2002. Accessed February 2, 2005.
- 2 Gei AF, Hankins GD. Cardiac disease and pregnancy. Obstet Gynecol Clin North Am. 2001; 28: 465–512.
- 3 Pattinson B. Saving mothers. Second report on confidential enquiries into maternal deaths in South Africa 1999–2001. Department of Health, Republic of South Africa, Government Printer; 2003.
- 4 Wren C, O'Sullivan JJ. Survival with congenital heart disease and need for follow up in adult life. Heart. 2001; 85: 438–443.
- 5 Siu SC, Sermer M, Colman JM, et al. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001; 104: 515–521.
- 6 Siu SC, Sermer M, Harrison DA, et al. Risk and predictors for pregnancy-related complications in women with heart disease. Circulation. 1997; 96: 2789–2794.
- 7 Presbitero P, Somerville J, Stone S, Aruta E, Spiegelhalter D, Rabajoli F. Pregnancy in cyanotic congenital heart disease. Outcome of mother and fetus. Circulation. 1994; 89: 2673–2676.
- 8 Garite TJ, Clark R, Thorp JA. Intrauterine growth restriction increases morbidity and mortality among premature neonates. Am J Obstet Gynecol. 2004; 191: 481–487.
- 9 Botto LD, May K, Fernhoff PM, et al. A population-based study of the 22q11.2 deletion: phenotype, incidence, and contribution to major birth defects in the population. Pediatrics. 2003; 112: 101–107.
- 10 Goldmuntz E, Clark BJ, Mitchell LE, et al. Frequency of 22q11 deletions in patients with conotruncal defects. J Am Coll Cardiol. 1998; 32: 492–498.
- 11 Antman EM. Current diagnosis and prescription for Marfan syndrome: when to operate. J Card Surg. 1994; 9(2 suppl): 174–176.
- 12 Immer FF, Bansi AG, Immer-Bansi AS, et al. Aortic dissection in pregnancy: analysis of risk factors and outcome. Ann Thorac Surg. 2003; 76: 309–314.
- 13 Hart MV, Morton MJ, Hosenpud JD, Metcalfe J. Aortic function during normal human pregnancy. Am J Obstet Gynecol. 1986; 154: 887–891.
- 14 Groenink M, Lohuis TA, Tijssen JG, et al. Survival and complication free survival in Marfan's syndrome: implications of current guidelines. Heart. 1999; 82: 499–504.
- 15 Silverman DI, Gray J, Roman MJ, et al. Family history of severe cardiovascular disease in Marfan syndrome is associated with increased aortic diameter and decreased survival. J Am Coll Cardiol. 1995; 26: 1062–1067.
- 16 Shores J, Berger KR, Murphy EA, Pyeritz RE. Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome. N Engl J Med. 1994; 330: 1335–1341.
- 17 Rossiter JP, Repke JT, Morales AJ, Murphy EA, Pyeritz RE. A prospective longitudinal evaluation of pregnancy in the Marfan syndrome. Am J Obstet Gynecol. 1995; 173: 1599–1606.
- 18 Von Dadelszen P, Ornstein MP, Bull SB, Logan AG, Koren G, Magee LA. Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis. Lancet. 2000; 355(9198): 87–92.
- 19 Lip GY, Beevers M, Churchill D, Shaffer LM, Beevers DG. Effect of atenolol on birth weight. Am J Cardiol. 1997; 79: 1436–1438.
- 20 Steer PJ. Pregnancy and contraception. In: MA Gatzoulis, L Swan, J Therrien, GA Pantely, eds. Adult Congenital Heart Disease: A Practical Guide. Oxford: BMJ/Blackwell Publishing Ltd; 2005: 16–35.
- 21 Weiss BM, Zemp L, Seifert B, Hess OM. Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996. J Am Coll Cardiol. 1998; 31: 1650–1657.
- 22 Daliento L, Somerville J, Presbitero P, et al. Eisenmenger syndrome. Factors relating to deterioration and death. Eur Heart J. 1998; 19: 1845–1855.
- 23 Yentis SM, Steer PJ, Plaat F. Eisenmenger's syndrome in pregnancy: maternal and fetal mortality in the 1990s. Br J Obstet Gynaecol. 1998; 105: 921–922.
- 24 Hannah ME, Hannah WJ, Hewson SA, Hodnett ED, Saigal S, Willan AR. Planned caesarean section versus planned vaginal birth for breech presentation at term: a randomised multicentre trial. Term Breech Trial Collaborative Group. Lancet. 2000; 356(9239): 1375–1383.
- 25 Rao TL, El-Etr AA. Anticoagulation following placement of epidural and subarachnoid catheters: an evaluation of neurologic sequelae. Anesthesiology. 1981; 55: 618–620.
- 26 Secher NJ, Arnsbo P, Wallin L. Haemodynamic effects of oxytocin (syntocinon) and methyl ergometrine (methergin) on the systemic and pulmonary circulations of pregnant anaesthetized women. Acta Obstet Gynecol Scand. 1978; 57: 97–103.
- 27 Perloff JK, Rosove MH, Child JS, Wright GB. Adults with cyanotic congenital heart disease: hematologic management. Ann Intern Med. 1988; 109: 406–413.
- 28 Tempe DK, Virmani S. Coagulation abnormalities in patients with cyanotic congenital heart disease. J Cardiothorac Vasc Anesth. 2002; 16: 752–765.
- 29 Hayman RG, Arulkumaran S, Steer PJ. Uterine compression sutures: surgical management of postpartum hemorrhage. Obstet Gynecol. 2002; 99: 502–506.
- 30 Bates SM, Ginsberg JS. Anticoagulants in pregnancy: fetal effects. Baillieres Clin Obstet Gynaecol. 1997; 11: 479–488.
- 31 Ginberg JS, Chan WS, Bates SM, Kaatz S. Anticoagulation of pregnant women with mechanical heart valves. Arch Intern Med. 2003; 163: 694–698.
- 32 Cotrufo M, De Feo M, De Santo LS, et al. Risk of warfarin during pregnancy with mechanical valve prostheses. Obstet Gynecol. 2002; 99: 35–40.
- 33 Vitale N, De Feo M, De Santo LS, Pollice A, Tedesco N, Cotrufo M. Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves. J Am Coll Cardiol. 1999; 33: 1637–1641.
- 34 Lovenox Injection [package insert]. Bridgewater, NJ: Aventis Pharmaceuticals Inc; 2002.
- 35 Barbour LA, Oja JL, Schultz LK. A prospective trial that demonstrates that dalteparin requirements increase in pregnancy to maintain therapeutic levels of anticoagulation. Am J Obstet Gynecol. 2004; 191: 1024–1029.
- 36 Reimold SC, Rutherford JD. Vavlular heart disease in pregnancy. N Engl J Med 2003; 349: 52–60.
- 37 Arias F, Pineda J. Aortic stenosis and pregnancy. J Reprod Med. 1978; 20: 229–232.
- 38 Silversides CK, Colman JM, Sermer M, Farine D, Siu SC. Early and intermediate-term outcomes of pregnancy with congenital aortic stenosis. Am J Cardiol. 2003; 91: 1386–1389.
- 39 Angel JL, Chapman C, Knuppel RA, Morales WJ, Sims CJ. Percutaneous balloon aortic valvuloplasty in pregnancy. Obstet Gynecol. 1988; 72: 438–440.
- 40 Pomini F, Mercogliano D, Cavalletti C, Caruso A, Pomini P. Cardiopulmonary bypass in pregnancy. Ann Thorac Surg. 1996; 61: 259–268.
- 41 Suntharalingam G, Dob D, Yentis SM. Obstetric epidural analgesia in aortic stenosis: a low-dose technique for labour and instrumental delivery. Int J Obstet Anesth. 2001; 10: 129–134.
- 42 Bartalena L, Bogazzi F, Braverman LE, Martino E. Effects of amiodarone administration during pregnancy on neonatal thyroid function and subsequent neurodevelopment. J Endocrinol Invest. 2001; 24: 116–130.
- 43 Therrien J, Barnes I, Somerville J. Outcome of pregnancy in patients with congenitally corrected transposition of the great arteries. Am J Cardiol. 1999; 84: 820–824.
- 44 Chugh R, Perloff JK, Ludbrook PA, et al. The impact of pregnancy on function of the subaortic morphologic right ventricle in d or l transposition of the great arteries. American Heart Association; 2001. Abstract.
- 45 Lilford RJ, Van Coeverden deGroot HA, Moore PJ, Bingham P. The relative risks of caesarean section (intrapartum and elective) and vaginal delivery: a detailed analysis to exclude the effects of medical disorders and other acute preexisting physiological disturbances. Br J Obstet Gynaecol. 1990; 97: 883–892.
- 46 Barnes EJ, Eben F, Patterson D. Direct current cardioversion during pregnancy should be performed with facilities available for fetal monitoring and emergency caesarean section. BJOG. 2002; 109: 1406–1407.
- 47 Burg JR, Dodek A, Kloster FE, Metcalfe J. Alterations of systolic time intervals during pregnancy. Circulation. 1974; 49: 560–564.
- 48 Clapp JF, Seaward BL, Sleamaker RH, Hiser J. Maternal physiologic adaptations to early human pregnancy. Am J Obstet Gynecol. 1988; 159: 1456–1460.
- 49 Robson SC, Hunter S, Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol. 1989; 256: 1060–1065.
- 50 Edouard DA, Pannier BM, London GM, Cuche JL, Safar ME. Venous and arterial behaviour during normal pregnancy. Am J Physiol. 1998; 274: 1605–1612.
- 51 Task Force on the Management of Cardiovascular Diseases During Pregnancy of the European Society of Cardiology. Expert consensus document on management of cardiovascular diseases during pregnancy. Eur Heart J. 2003; 24: 761–781.
- 52 Siu SC, Colman JM, Sorensen S, et al. Adverse neonatal and cardiac outcomes are more common in pregnant women with cardiac disease. Circulation. 2002; 105: 2179–2184.
- 53 Burn J, Brennan P, Little J, et al. Recurrence risks in offspring of adults with major heart defects: results from first cohort of British collaborative study. Lancet. 1998; 351(9099): 311–316.