Functional subtypes of renal α1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension
A ARMENIA
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Department of Pharmacy, Faculty of Mathematical and Natural Sciences, University of Andalas, Padang, West Sumatra 25163, Indonesia.
Search for more papers by this authorCorresponding Author
Munavvar Abdul SATTAR
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Correspondence to Dr Munavvar Abdul SATTAR. Phn 60-4653-2251 [email protected]; [email protected]Search for more papers by this authorNor Azizan ABDULLAH
Department of Pharmacology, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Search for more papers by this authorMd Abdul Hye KHAN
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Search for more papers by this authorEdward James JOHNS
Department of Physiology, University College Cork, Cork, Ireland
Search for more papers by this authorA ARMENIA
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Department of Pharmacy, Faculty of Mathematical and Natural Sciences, University of Andalas, Padang, West Sumatra 25163, Indonesia.
Search for more papers by this authorCorresponding Author
Munavvar Abdul SATTAR
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Correspondence to Dr Munavvar Abdul SATTAR. Phn 60-4653-2251 [email protected]; [email protected]Search for more papers by this authorNor Azizan ABDULLAH
Department of Pharmacology, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Search for more papers by this authorMd Abdul Hye KHAN
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Search for more papers by this authorEdward James JOHNS
Department of Physiology, University College Cork, Cork, Ireland
Search for more papers by this authorAbstract
Aim: This study investigates the subtypes of the α1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats. Methods: The renal blood flow responses to renal nerve stimulation, noradrenaline, phenylephrine, and methoxamine were measured in the absence and presence of nitrendipine, 5-methylurapidil, chloroethylclonidine and BMY 7378. Results: The renal vasoconstrictor responses were markedly attenuated by nitrendipine and 5-methylurapidil in the diabetic rats (all P<0.05). In the non-diabetic rats, these responses were markedly attenuated by nitrendipine, 5-methylurapidil, and BMY 7378 (all P<0.05). In both experimental groups, chloroethylclonidine markedly accentuated the renal vasoconstrictions caused by all the adrenergic stimuli (all P<0.05). Conclusion: These observations indicate that α1A-adrenoceptor subtypes play a major role in mediating adrenergically-induced renal vasoconstriction in the diabetic 2K1C Goldblatt hypertensive rats. In the non-diabetic 2K1C Goldblatt hypertensive rats, contributions of α1A and α1D-adrenoceptor subtypes were proposed. Apart from post-synaptic α1-adrenoceptors, both in the diabetic and non-diabetic 2K1C Goldblatt hypertensive rats, the potential involvement of presynaptic α1-adrenoceptors is also suggested.
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