Distribution of killer cell immunoglobulin-like receptor genes in Poles
E. Majorczyk
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorW. Łuszczek
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorI. Nowak
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorA. Pawlik
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland and
Search for more papers by this authorA. Wiśniewski
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorM. Jasek
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorP. Kuśnierczyk
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Jan Długosz Paedagogical University, Częstochowa, Poland
Search for more papers by this authorE. Majorczyk
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorW. Łuszczek
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorI. Nowak
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorA. Pawlik
Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland and
Search for more papers by this authorA. Wiśniewski
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorM. Jasek
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Search for more papers by this authorP. Kuśnierczyk
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute, Polish Academy of Sciences, Wrocław, Poland
Jan Długosz Paedagogical University, Częstochowa, Poland
Search for more papers by this authorSummary
Killer cell immunoglobulin-like receptors (KIRs) present on natural killer cells and minor subpopulations of T cells recognize class I human leucocyte antigen (HLA) molecules on the surface of target cells. Humans differ by the presence or absence of some KIR genes on their chromosomes. As KIRs are important for the outcome of tissue transplantation (particularly for haematopoietic stem cell transplantation) and possibly for pregnancy and autoimmune diseases, knowledge of the KIR gene distribution in a given human population is of practical value. Therefore, we tested 363 healthy individuals from Western Poland for the presence or absence of KIR genes. Results are compared with those published for other human populations. KIR gene frequencies in Poles are close to these in other Caucasoids but different from those in Asian and African populations, and particularly distant from those in Australian Aborigines.
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